Intermediate of API

198904-85-7

  • Product Name：tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate
  • Molecular Formula：C17H21N3O2
  • Specifications：99%
  • Molecular Weight：299.373
Inquiry

Product Details;

CasNo： 198904-85-7

Molecular Formula： C17H21N3O2

Appearance： white solid

Pharmaceutical Intermediates 198904-85-7 Powder with Best Price

  • Molecular Formula:C17H21N3O2
  • Molecular Weight:299.373
  • Appearance/Colour:white solid 
  • Melting Point:74-77 °C 
  • Refractive Index:1.555 
  • PKA:10.38±0.43(Predicted) 
  • PSA：63.25000 
  • Density:1.117 g/cm3 
  • LogP:4.05970 

tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate(Cas 198904-85-7) Usage

Chemical Properties

White Solid

Uses

An intermediate for the preparation of antiviral protease inhibitors.
Synonyms TERT-BUTYL 2-(4-(PYRIDIN-2-YL)BENZYL)HYDRAZINECARBOXYLATE; 1-Boc-2-[4-(2-pyridinyl)benzylidene]hydrazine; Hydrazinecarboxylic acid, 2-[[4-(2-pyridinyl)phenyl]methyl]-, 1,1-dimethylethyl ester; Tert-butyl N-[(4-pyridin-2-ylphenyl)methylamino]carbamate; SCHEMBL6692; DTXSID40430867; T-butyl-2-[4-(pyridin-2-yl)benzyl] hydrazine carboxylate; tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazine-1-carboxylate; BCP28313; MFCD04035550; AKOS015908769

Isomeric SMILES: CC(C)(C)OC(=O)NNCC1=CC=C(C=C1)C2=CC=CC=N2  
InChIKey: GIMJTKJSKPENNG-UHFFFAOYSA-N  
InChI: InChI=1S/C17H21N3O2/c1-17(2,3)22-16(21)20-19-12-13-7-9-14(10-8-13)15-6-4-5-11-18-15/h4-11,19H,12H2,1-3H3,(H,20,21)  

198904-85-7 Relevant articles

A scalable synthesis of biaryl unit of the HIV protease inhibitor atazanavir

Katari, Naresh K.,Prasad, Malavattu G.,Reddy, Pedavenkatagari N.,Vijayalakshmi, Chapala

, p. 68 - 72 (2020/01/23)

Atazanavir is one of the most prescribed...

Industrial production method of atazanavir intermediate tert-butyl 2-[4-(2-pyridyl)benzyl]-carbazate

-

Paragraph 0035; 0045-0047; 0048; 0058-0060, (2019/04/17)

The invention relates to the technical f...

Preparation method of tert-butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate

-

Paragraph 0042; 0043, (2017/05/23)

The invention discloses a preparation me...

Synthesis and biological evaluation of Hydrazone derivatives as antifungal agents

Casanova, Bruna B.,Muniz, Mauro N.,De Oliveira, Thayse,De Oliveira, Luís Flavio,Machado, Michel M.,Fuentefria, Alexandre M.,Gosmann, Grace,Gnoatto, Simone C. B.

, p. 9229 - 9241 (2016/08/31)

Emerging yeasts are among the most preva...

198904-85-7 Process route

2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
198904-84-6

2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester

2-(4-methylphenyl)pyridine
4467-06-5

2-(4-methylphenyl)pyridine

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
Conditions Yield
With hydrogen; triethylamine; 5%-palladium/activated carbon; at 40 ℃; for 5h; under 760.051 Torr;
99.17%
0.69%
With hydrogen; sodium carbonate; 5%-palladium/activated carbon; at 40 ℃; for 5h; under 760.051 Torr;
99.16%
0.25%
With hydrogen; 5%-palladium/activated carbon; In methanol; at 50 ℃; for 5h; under 760.051 Torr;
97.11%
2.69%
at 40 - 62 ℃; for 5h; under 1520.1 Torr; Hydrogen/nitrogen (1/2);
97.2%
0.1%
With hydrogen; 5%-palladium/activated carbon; at 5 - 58 ℃; for 5 - 8h; under 1520.1 Torr; Nitrogen gas;
94.41%
2.11%
N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine
857904-11-1

N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
Conditions Yield
With hydrogen; palladium 10% on activated carbon; In methanol; for 4h;
98%
With hydrogen; palladium 10% on activated carbon; In methanol;
98%
With hydrogen; palladium on activated charcoal; In methanol;
89%

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198904-85-7 Downstream products

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