Intermediate of API

38083-17-9

  • Product Name：Climbazole
  • Molecular Formula：C15H17ClN2O2
  • Specifications：99%
  • Molecular Weight：292.765
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Product Details;

CasNo： 38083-17-9

Molecular Formula： C15H17ClN2O2

Appearance： off-white to pale yellow crystalline powder

High Grade Fast Delivery Factory Sells High Purity 99% Hot Sale Climbazole 38083-17-9 White Powder Low Price In Bulk Supply In Stock For Sale

  • Molecular Formula:C15H17ClN2O2
  • Molecular Weight:292.765
  • Appearance/Colour:off-white to pale yellow crystalline powder 
  • Vapor Pressure:3.34E-08mmHg at 25°C 
  • Melting Point:96-100 °C 
  • Refractive Index:1.56 
  • Boiling Point:447.5 °C at 760 mmHg 
  • PKA:5.66±0.22(Predicted) 
  • Flash Point:224.4 °C 
  • PSA：44.12000 
  • Density:1.17 g/cm3 
  • LogP:3.72930 

Climbazole(Cas 38083-17-9) Usage

Risks to the environment

Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms.

Description

(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.

Chemical Properties

White Solid

Uses

Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.

Hazard

Moderately toxic by ingestion. Low toxicity by skin contact.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3

38083-17-9 Relevant articles

Preparation method of climbazole

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Paragraph 0048; 0061; 0062; 0064; 0067; 0070; 0073, (2018/04/03)

The invention discloses a preparation me...

NOVEL NEISSERIA MENINGITIDIS SEROGROUP Y OLIGOMER AND PROCESS FOR SYNTHESIZING THEREOF

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Paragraph 0048; 0061; 0064; 0067; 0070; 0073, (2018/04/03)

The present invention relates to novel o...

38083-17-9 Process route

1H-imidazole
288-32-4

1H-imidazole

1-(4-chlorophenoxy)-1-chloro-3,3-dimethyl-butan-2-one
57000-78-9

1-(4-chlorophenoxy)-1-chloro-3,3-dimethyl-butan-2-one

climbazole
38083-17-9

climbazole

Conditions
Conditions Yield
With N,N-dimethylbenzamide; In toluene; at 100 - 110 ℃; for 4h; Solvent; Large scale;
91%
With N,N-dimethylbenzamide; In toluene; at 100 - 110 ℃; for 4h; Solvent; Large scale;
climbazole
38083-17-9

climbazole

Conditions
Conditions Yield

38083-17-9 Upstream products

  • 288-32-4
    288-32-4

    1H-imidazole

  • 57000-78-9
    57000-78-9

    1-(4-chlorophenoxy)-1-chloro-3,3-dimethyl-butan-2-one

38083-17-9 Downstream products

  • 55362-18-0
    55362-18-0

    1-(4'-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-hydroxy-butane

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