Intermediate of API

870-46-2

  • Product Name:Tert-butyl carbazate
  • Molecular Formula:C5H12N2O2
  • Specifications:99%
  • Molecular Weight:132.162
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Product Details;

CasNo: 870-46-2

Molecular Formula: C5H12N2O2

Appearance: White to pale yellow lumps

Chinese Factory Supply Top Purity Tert-butyl carbazate 870-46-2 In Medicine

  • Molecular Formula:C5H12N2O2
  • Molecular Weight:132.162
  • Appearance/Colour:White to pale yellow lumps 
  • Vapor Pressure:0.024mmHg at 25°C 
  • Melting Point:39-42 °C(lit.) 
  • Refractive Index:1.4496 (estimate) 
  • Boiling Point:303.6 °C at 760 mmHg 
  • PKA:10.74±0.20(Predicted) 
  • Flash Point:94.7 °C 
  • PSA:64.35000 
  • Density:1.039 g/cm3 
  • LogP:1.47600 

tert-Butyl carbazate(Cas 870-46-2) Usage

Chemical Properties

White to pale yellow lumps

Uses

Starting material for preparing BOC-azide, a reagent to introduce the BOC amino protection.

Synonyms tert-Butyl carbazate; 870-46-2; tert-Butyl hydrazinecarboxylate; t-Butyl carbazate; tert-butyl N-aminocarbamate

Purification Methods

Distil it in a Claisen flask with a water or oil bath at ca 80o. After a couple of drops have distilled, the carbazate is collected as an oil which solidifies to a snow white solid. It can be crystallised with 90% recovery from a 1:1 mixture of pet ether (b 30-60o) and pet ether (b 60-70o). [Carpino et al. Org Synth Coll Vol V 166 1973, Caprino et al. Org Synth 44 20 1964, Beilstein 3 IV 175.]

Isomeric SMILES: CC(C)(C)OC(=O)NN  
InChIKey: DKACXUFSLUYRFU-UHFFFAOYSA-N  
InChI: InChI=1S/C5H12N2O2/c1-5(2,3)9-4(8)7-6/h6H2,1-3H3,(H,7,8)  

870-46-2 Relevant articles

A novel poly(l -glutamic acid) dendrimer based drug delivery system with both pH-sensitive and targeting functions

Yuan, Hui,Luo, Kui,Lai, Yusi,Pu, Yuji,He, Bin,Wang, Gang,Wu, Yao,Gu, Zhongwei

, p. 953 - 962 (2010)

The functionalization of pH-sensitivenes...

Synthesis of Diprotected Monosubstituted Hydrazine Derivatives from tert-Butyl Carbazates and Boronic Acids

GW Kabalka, SK Guchhait

Org. Lett. 2003, 5, 22, 4129–4131

Diprotected monosubstituted hydrazine derivatives have been prepared via the reaction of tert-butyl carbazates with boronic acids catalyzed by cuprous chloride at room temperature.

Sitagliptin impurity and preparation method and detection method thereof

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Paragraph 0046; 0047, (2021/10/05)

The novel impurity can provide standard ...

Elastic targeting polypeptide-based medicine-carrying nanoparticle as well as preparation method and application thereof

-

Paragraph 0029-0031; 0039-0041, (2020/07/15)

The invention discloses an elastic targe...

Synthesis and Antimicrobial activity of Some 1, 3, 4-Oxadiazoles-2-thione and 1, 2, 4-Triazoles Derivatives from Tert-Butyl Carbazate

Ghoneim, Amira A; Mohamed, Sahar A.

Oriental Journal of Chemistry; Bhopal Vol. 29, Iss. 2,  (2013): 525-531.

… in two steps from tert-butyl carbazate 1. The first step was the preparation of 4-carboxylic-acid-hydrazidethioformamido-semi-carbazide 2 by treating the carbazate 1 with ammonium …

870-46-2 Process route

N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine
20866-46-0

N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine

t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

N-(tert-butoxycarbonyl)-L-histidine
17791-52-5

N-(tert-butoxycarbonyl)-L-histidine

Conditions
Conditions Yield
In ethanol; for 0.166667h; Yield given. Yields of byproduct given; Heating;
 
di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

Conditions
Conditions Yield
With hydrazine hydrate;
97%
With hydrazine hydrate; In isopropyl alcohol; at 0 ℃; for 2h;
97%
With hydrogenchloride; hydrazine hydrate; In methanol; at 0 - 10 ℃; Solvent; Temperature;
94.4%
With potassium carbonate; hydrazine hydrate; In 1,4-dioxane; water; at 20 ℃; for 12h;
93%
With hydrazine hydrate; In isopropyl alcohol; at 0 - 25 ℃;
93%
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃; Inert atmosphere;
90%
With hydrazine hydrate; toluene-4-sulfonic acid; In water; at -5 - 0 ℃; for 1.5h;
90%
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃; for 1h;
85%
With hydrazine hydrate; In isopropyl alcohol; at 0 - 10 ℃; for 0.5h; Cooling with ice;
80%
With hydrazine hydrate; In isopropyl alcohol; at 20 ℃; for 0.333333h;
78.1%
With hydrazine hydrate; In dichloromethane; isopropyl alcohol; at 0 - 20 ℃; for 0.333333h;
78%
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃; for 1h;
76%
With hydrazine hydrate; In isopropyl alcohol; at 20 ℃; for 2h;
75%
With hydrazine hydrate; In tetrahydrofuran; at 0 - 20 ℃;
74.4%
With hydrazine hydrate; In tetrahydrofuran; at 0 ℃; for 1h;
70%
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃; for 2h;
47%
With hydrazine hydrate; In isopropyl alcohol;
 
Multi-step reaction with 2 steps
1: 1 M K2CO3 / propan-2-ol / 1 h / 30 - 40 °C
2: ethanol / 0.17 h / Heating
With potassium carbonate; In ethanol; isopropyl alcohol;
 
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃;
 
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃;
 
With hydrazine hydrate; In dichloromethane; at 0 - 20 ℃; for 5h;
 
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃;
 

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