CasNo: 870-46-2
Molecular Formula: C5H12N2O2
Appearance: White to pale yellow lumps
Chemical Properties |
White to pale yellow lumps |
Uses |
Starting material for preparing BOC-azide, a reagent to introduce the BOC amino protection. |
Synonyms | tert-Butyl carbazate; 870-46-2; tert-Butyl hydrazinecarboxylate; t-Butyl carbazate; tert-butyl N-aminocarbamate |
Purification Methods |
Distil it in a Claisen flask with a water or oil bath at ca 80o. After a couple of drops have distilled, the carbazate is collected as an oil which solidifies to a snow white solid. It can be crystallised with 90% recovery from a 1:1 mixture of pet ether (b 30-60o) and pet ether (b 60-70o). [Carpino et al. Org Synth Coll Vol V 166 1973, Caprino et al. Org Synth 44 20 1964, Beilstein 3 IV 175.] |
Isomeric SMILES: CC(C)(C)OC(=O)NN
InChIKey: DKACXUFSLUYRFU-UHFFFAOYSA-N
InChI: InChI=1S/C5H12N2O2/c1-5(2,3)9-4(8)7-6/h6H2,1-3H3,(H,7,8)
The functionalization of pH-sensitivenes...
Diprotected monosubstituted hydrazine derivatives have been prepared via the reaction of tert-butyl carbazates with boronic acids catalyzed by cuprous chloride at room temperature.
The novel impurity can provide standard ...
The invention discloses an elastic targe...
… in two steps from tert-butyl carbazate 1. The first step was the preparation of 4-carboxylic-acid-hydrazidethioformamido-semi-carbazide 2 by treating the carbazate 1 with ammonium …
N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine
t-butoxycarbonylhydrazine
N-(tert-butoxycarbonyl)-L-histidine
Conditions | Yield |
---|---|
In ethanol; for 0.166667h; Yield given. Yields of byproduct given; Heating;
|
di-tert-butyl dicarbonate
t-butoxycarbonylhydrazine
Conditions | Yield |
---|---|
With hydrazine hydrate;
|
97% |
With hydrazine hydrate; In isopropyl alcohol; at 0 ℃; for 2h;
|
97% |
With hydrogenchloride; hydrazine hydrate; In methanol; at 0 - 10 ℃; Solvent; Temperature;
|
94.4% |
With potassium carbonate; hydrazine hydrate; In 1,4-dioxane; water; at 20 ℃; for 12h;
|
93% |
With hydrazine hydrate; In isopropyl alcohol; at 0 - 25 ℃;
|
93% |
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃; Inert atmosphere;
|
90% |
With hydrazine hydrate; toluene-4-sulfonic acid; In water; at -5 - 0 ℃; for 1.5h;
|
90% |
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃; for 1h;
|
85% |
With hydrazine hydrate; In isopropyl alcohol; at 0 - 10 ℃; for 0.5h; Cooling with ice;
|
80% |
With hydrazine hydrate; In isopropyl alcohol; at 20 ℃; for 0.333333h;
|
78.1% |
With hydrazine hydrate; In dichloromethane; isopropyl alcohol; at 0 - 20 ℃; for 0.333333h;
|
78% |
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃; for 1h;
|
76% |
With hydrazine hydrate; In isopropyl alcohol; at 20 ℃; for 2h;
|
75% |
With hydrazine hydrate; In tetrahydrofuran; at 0 - 20 ℃;
|
74.4% |
With hydrazine hydrate; In tetrahydrofuran; at 0 ℃; for 1h;
|
70% |
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃; for 2h;
|
47% |
With hydrazine hydrate; In isopropyl alcohol;
|
|
Multi-step reaction with 2 steps
1: 1 M K2CO3 / propan-2-ol / 1 h / 30 - 40 °C
2: ethanol / 0.17 h / Heating
With potassium carbonate; In ethanol; isopropyl alcohol;
|
|
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃;
|
|
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃;
|
|
With hydrazine hydrate; In dichloromethane; at 0 - 20 ℃; for 5h;
|
|
With hydrazine hydrate; In isopropyl alcohol; at 0 - 20 ℃;
|
S-Methyl-monothiokohlensaeure-tert.-butylester
tert-butyl phenyl carbonate
tert-butyl 2,2,2-trichloroacetate
α-Nitroisobuttersaeure-tert-butylester
1,2-bis(t-butyloxycarbonyl)hydrazine
N-(tert-butyloxycarbonyl) azide
t-butyl 3-benzylidenecarbazate
H-Leu-N2H2-Boc
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