Intermediate of API

445-27-2

  • Product Name：2'-Fluoroacetophenone
  • Molecular Formula：C8H7FO
  • Specifications：99%
  • Molecular Weight：138.141
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Product Details;

CasNo： 445-27-2

Molecular Formula： C8H7FO

Appearance： Clear colorless to light yellow or light green

High Grade Pharmaceutical Intermediates 2'-Fluoroacetophenone 445-27-2 Best Price

  • Molecular Formula:C8H7FO
  • Molecular Weight:138.141
  • Appearance/Colour:Clear colorless to light yellow or light green 
  • Melting Point:26-27 °C 
  • Refractive Index:n20/D 1.507(lit.)  
  • Boiling Point:180.8 °C at 760 mmHg 
  • Flash Point:67.5 °C 
  • PSA：17.07000 
  • Density:1.103 g/cm3 
  • LogP:2.02830 

2'-Fluoroacetophenone(Cas 445-27-2) Usage

Chemical Properties

clear colorless to light yellow or light green

Uses

2'-Fluoroacetophenone is used as starting reagent in the synthesis of ascididemin. It is used to produce 1-(2-piperidin-1-yl-phenyl)-ethanone by reaction with piperidine.

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 6179, 1990 DOI: 10.1016/S0040-4039(00)97018-7

General Description

The enantioselective reduction of 2′-fluoroacetophenone has been investigated.

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445-27-2 Process route

1-(2-fluorophenyl)ethanol
445-26-1

1-(2-fluorophenyl)ethanol

2'-Fluoroacetophenone
445-27-2

2'-Fluoroacetophenone

Conditions
Conditions Yield
With [(2-(benzoimidazol-2-yl)-6-(3,5-dimethylpyrazol-1-yl)pyridine)RuCl2(PPh3)]; potassium tert-butylate; acetone; In methanol; at 56 ℃; for 0.5h; under 750.075 Torr; Catalytic behavior; Inert atmosphere;
97%
With Langlois reagent; In acetonitrile; at 25 ℃; for 12h; Irradiation; Sealed tube;
89%
With calcomenite; potassium hydroxide; In toluene; for 28h; Reflux;
87%
With caesium carbonate; In toluene; at 110 ℃; for 18h;
77%
With tert.-butylhydroperoxide; In water; at 100 ℃; for 24h;
72%
With potassium tetrakis-μ-pyrophosphitodiplatinate(II); In water; at 20 ℃; for 8h; Inert atmosphere; Irradiation;
55%
With pyridinium chlorochromate; In dichloromethane;
With sodium hypochlorite; N-Bromosuccinimide; [(R,R)-(N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminato)]manganese(III) chloride; In dichloromethane; water; at 25 ℃; for 0.17h; chemoselective reaction;
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Trametes versicolor laccase; In tert-butyl methyl ether; at 30 ℃; for 16h; pH=5; Solvent; Reagent/catalyst; Catalytic behavior; Enzymatic reaction;
With [fac-N-(2-(diphenylphosphino)ethyl)-5,6,7,8-tetrahydroquinolin-8-amine]RuCl2(triphenylphosphine); potassium tert-butylate; In para-xylene; for 24h; Catalytic behavior; Reflux; Inert atmosphere;
With oxygen; at 120 ℃; for 12h;
With C44H52N2O4Ru; 4-methylmorpholine N-oxide; In acetonitrile; at 82 ℃; for 1h; Inert atmosphere;
87 %Chromat.
With dipropylene glycol dimethyl ether; oxygen; at 120 ℃;
o-fluorophenylboronic acid
1993-03-9

o-fluorophenylboronic acid

acetonitrile
75-05-8,26809-02-9

acetonitrile

2'-Fluoroacetophenone
445-27-2

2'-Fluoroacetophenone

Conditions
Conditions Yield
With 1,10-Phenanthroline; nickel(II) bromide diethylene glycol dimethyl ether; sodium hydrogencarbonate; In water; at 100 ℃; for 5h; Autoclave;
89%

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