Intermediate of API

137-00-8

  • Product Name：5-(2-Hydroxyethyl)-4-methylthiazole
  • Molecular Formula：C6H9NOS
  • Specifications：99%
  • Molecular Weight：143.21
Inquiry

Product Details;

CasNo： 137-00-8

Molecular Formula： C6H9NOS

Appearance： Colorless to light yellow liquid

Top Purity Food Additives 5-(2-Hydroxyethyl)-4-methylthiazole 137-00-8 with Good Price

  • Molecular Formula:C6H9NOS
  • Molecular Weight:143.21
  • Appearance/Colour:Colorless to light yellow liquid 
  • Vapor Pressure:0.00297mmHg at 25°C 
  • Melting Point:<25 °C 
  • Refractive Index:n20/D 1.550(lit.)  
  • Boiling Point:272.4 °C at 760 mmHg 
  • PKA:14.58±0.10(Predicted) 
  • Flash Point:109.7 °C 
  • PSA：61.36000 
  • Density:1.206 g/cm3 
  • LogP:0.98630 

5-(2-Hydroxyethyl)-4-methylthiazole(Cas 137-00-8) Usage

Content analysis

It was determined by gas chromatography (GT-10-4) using a nonpolar column method.

Toxicity

GRAS (FEMA)

Usage limit FEMA

soft drinks, cold drinks, candy, baked goods, jelly, pudding, jelly sugar, seasonings, meat products, meat soup, milk and dairy products as well as cereal product: 55.0mg/kg.

Application

5-(2-hydroxyethyl)-4-methylthiazole is  the precursor of the monomer MTZ. Used as temporarily allowable food spices; For nuts, dairy products, meat products, etc., as pharmaceutical intermediates; Used for the deployment of chocolate, milk and nuts

Preparation

It is obtained from the reduction of 4-methyl thiazole 5-ethyl acetate reduction with lithium aluminum hydride. It may be prepared by reduction of ethyl- 4-methylthiazole-5-acetate using LiAlH4; by condensation of thioformamide with bromoacetopropanol or with y,y-dichloro-y,ydiacetodipropyl ether.

Occurrence

Reported found in grilled and roasted beef, cognac, brandy, Finnish whiskey, cocoa, peanuts, beans and malt.

Uses

5-(2-Hydroxyethyl)-4-methylthiazole, a metabolic intermediate in the biosynthesis of thiamine, has been used in the synthesis of novel thiazolium halogenide ionic liquids. 5-(2-hydroxyethyl)-4-methylthiazole (HMT) is the analog compound of vitamin B1, and can be used as the counter-cation precursor.

Definition

ChEBI: A 1,3-thiazole that is thiazole substituted by a methyl group at position 4 and a 2-hydroxyethyl group at position 5.

Taste threshold values

Taste characteristics at 20 ppm: meaty, brothy, roasted, metallic and nutty.

InChI:InChI=1/C6H9NOS/c1-5-6(2-3-8)9-4-7-5/h4,8H,2-3H2,1H3

137-00-8 Relevant articles

Analysis of Thiamine in Pinto Beans by Gas Chromatography of the Sulfite Cleavage Product 5-(2-Hydroxyethyl)-4-methylthiazole

Richard M Seifert, Charlotte Fung Miller

, Journal of Association of Official Analytical Chemists, Volume 56, Issue 5, 1 September 1973, Pages 1273–1276

Thiamine is extracted and then quantitatively split by sulfite treatment to give the ether-extractable 5-(2-hydroxyethyl)-4-methylthiazole. The thiazole was analyzed by GLC. Its purity and identity were confirmed by mass spectrometry and GLC retention time.

Mechanistic studies on thiaminase I: Identification of the product of thiamin degradation in the absence of the nucleophilic cosubstrate

Wu, Min,Papish, Elizabeth T.,Begley, Tadhg P.

, p. 45 - 48 (2000)

Thiaminase I catalyzes the decomposition...

The crystal structure of the complex dibromobis [5-(2-hydroxyethyl)-4-methylthiazole] cobalt (II)

MR Caira, LR Nassimbeni

, Acta Cryst. (1974). B30, 2332-2337

The dark blue crystals were shown to have the composition Co-[5- (2-hydroxyethyl)-4-methylthiazole]2Br2 by microanal- ysis.

KHF2: A mild and selective desilylating agent for phenol tert-butyldimethylsilyl (TBDMS) ethers

Lakshman, Mahesh K.,Tine, Fatou A.,Khandaker, Tashrique A.,Basava, Vikram,Agyemang, Nana B.,Benavidez, Michael S.A.,Ga?i, Marikone,Guerrera, Lisa,Zajc, Barbara

supporting information, p. 381 - 385 (2017/02/10)

TBDMS (t-BuMe2Si, tert-butyldimethylsily...

137-00-8 Process route

5-(2-hydroxy-ethyl)-4-methyl-3-(1-phenyl-ethyl)-thiazolium; bromide
75501-62-1

5-(2-hydroxy-ethyl)-4-methyl-3-(1-phenyl-ethyl)-thiazolium; bromide

5-hydroxyethyl-4-methylthiazole
137-00-8,8042-97-5

5-hydroxyethyl-4-methylthiazole

1-ethoxy-1-phenylethane
3299-05-6

1-ethoxy-1-phenylethane

Conditions
Conditions Yield
 
  
D-xylose
58-86-6

D-xylose

vitamin B<sub>1</sub>
59-43-8

vitamin B1

4,5-Dihydro-2-methylthiophen-3-(2H)-on
74015-70-6,13679-85-1

4,5-Dihydro-2-methylthiophen-3-(2H)-on

5-hydroxyethyl-4-methylthiazole
137-00-8,8042-97-5

5-hydroxyethyl-4-methylthiazole

2-methyltetrahydrofuran-3-one
3188-00-9

2-methyltetrahydrofuran-3-one

3-mercapto-2-butanone
40789-98-8

3-mercapto-2-butanone

3-mercaptopentan-2-one
67633-97-0

3-mercaptopentan-2-one

2-methylfuran-3-thiol
28588-74-1

2-methylfuran-3-thiol

Conditions
Conditions Yield
With L-Cysteine; at 145 ℃; for 0.333333h; pH=7; aq. phosphate buffer;
 

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137-00-8 Downstream products

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