Intermediate of API

71675-87-1

  • Product Name：4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
  • Molecular Formula：C10H13NO5S
  • Specifications：99%
  • Molecular Weight：259.283
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Product Details;

CasNo： 71675-87-1

Molecular Formula： C10H13NO5S

Appearance： Slightly pink solid

Fast Delivery 4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid 71675-87-1 In Medicine Best Price

  • Molecular Formula:C10H13NO5S
  • Molecular Weight:259.283
  • Appearance/Colour:Slightly pink solid 
  • Vapor Pressure:4.78E-12mmHg at 25°C 
  • Melting Point:82-85 °C 
  • Refractive Index:1.568 
  • Boiling Point:529.6 °C at 760 mmHg 
  • PKA:4.09±0.10(Predicted) 
  • Flash Point:274.1 °C 
  • PSA：115.07000 
  • Density:1.39 g/cm3 
  • LogP:2.43120 

4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid(Cas 71675-87-1) Usage

Chemical Properties

Slightly Pink Solid

Uses

An impurity found in amisulpride (A633250). Amisulpride EP Impurity E

Flammability and Explosibility

Notclassified

InChI:InChI=1/C10H13NO5S/c1-3-17(14,15)9-4-6(10(12)13)8(16-2)5-7(9)11/h4-5H,3,11H2,1-2H3,(H,12,13)

71675-87-1 Relevant articles

AN IMPROVED PROCESS FOR PREPARATION OF AMISULPRIDE

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, (2012/01/06)

The present invention is related to a no...

Compositions of (S) (-)-amisulpride

-

, (2008/06/13)

A composition is provided comprising an ...

71675-87-1 Process route

methyl 4-amino-5-(ethylthio)-2-methoxybenzoate
1119455-01-4

methyl 4-amino-5-(ethylthio)-2-methoxybenzoate

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

Conditions
Conditions Yield
methyl 4-amino-5-(ethylthio)-2-methoxybenzoate; With dihydrogen peroxide; sodium tungstate; In isopropyl alcohol; at 40 - 45 ℃; Industry scale;
With water; sodium hydroxide; In isopropyl alcohol; at 60 - 65 ℃; Industry scale;
With hydrogenchloride; In water; isopropyl alcohol; pH=4 - 4.5; Industry scale;
82%
Multi-step reaction with 2 steps
1.1: sodium hydroxide; water / methanol / 65 °C / Industry scale
1.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale
2.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C
With water; dihydrogen peroxide; sodium hydroxide; sodium tungstate; In methanol; water;
2-methoxy-4-amino-5-ethylthio benzoic acid

2-methoxy-4-amino-5-ethylthio benzoic acid

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid
71675-87-1

2-methoxy-4-amino-5-ethylsulphonyl benzoic acid

Conditions
Conditions Yield
With dihydrogen peroxide; sodium tungstate; In methanol; water; at 20 - 30 ℃; for 5h; Product distribution / selectivity;
80%

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