Intermediate of API

294-90-6

  • Product Name：Cyclen
  • Molecular Formula：C8H20N4
  • Specifications：99%
  • Molecular Weight：172.274
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Product Details;

CasNo： 294-90-6

Molecular Formula： C8H20N4

Appearance： off- white to slightly yellow crystalline powder

High Quality Cyclen 294-90-6 In Bulk Supply with Best Price

  • Molecular Formula:C8H20N4
  • Molecular Weight:172.274
  • Appearance/Colour:off- white to slightly yellow crystalline powder 
  • Vapor Pressure:0.00309mmHg at 25°C 
  • Melting Point:108-113 °C 
  • Refractive Index:1.5872 (estimate) 
  • Boiling Point:283.8 °C at 760 mmHg 
  • PKA:10.53±0.20(Predicted) 
  • Flash Point:129.5 °C 
  • PSA：48.12000 
  • Density:0.874 g/cm3 
  • LogP:-0.32640 

Cyclen(Cas 294-90-6) Usage

Chemical Properties

ALMOST WHITE TO SLIGHTLY YELLOW CRYSTALLINE POWDER

Uses

Macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well ass other imaging) agents. The use of cyclen (1,4,7,10-tetraazacyclododecane) as a blocking ligand enables assembly of the mixed-valence square complex [(cyclen) 4 Ru 4 (pz) 4 ] 9+ (pz = pyrazine).

General Description

Cyclen is a microcyclic tetramine that can be used as a ligand that forms a co-ordination linkage with the surface metal cations. It can be used as a synthetic precursor. It can be prepared by S-alkylation of dithiooxamide with an excess amount of bromoethane.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2/p+4

294-90-6 Relevant articles

Nanofiltration membrane comprising structural regulator Cyclen for efficient Li+/Mg2+ separation

Tingyu Li, Xinzhu Zhang, Yu Zhang, Jixiao Wang, Zhi Wang, Song Zhao

, Desalination Volume 556, 15 June 2023, 116575

Specifically, precisely regulated NF membranes were prepared through a conventional IP process with Cyclen as the structural regulator, as well as PEI and TMC as the reactive monomers.

Novel "Multipoint" Molecular Recognition of Nucleobases by a New Zinc(II) Complex of Acridine-Pendant Cyclen (Cyclen = 1,4,7,10-Tetraazacyclododecane)

Mitsuhiko Shionoya, Takuya Ikeda, Eiichi Kimura, and Motoo Shiro

, J. Am. Chem. Soc. 1994, 116, 9, 3848–3859

A zine(II) complex of acridine-pendant cyclen, 4.2ClO4 (cyclen=1.4.7,10-tetraazacyclododecane, 1), has been designed and synthesized as a new "multipoint" nucleobase receptor molecule in aqueous solution at physiological pH and compared with a Znll pendantless cyclen complex 2 recently discovered (ref 9) as a highly slective host for dT (deoxythymidine) and U (uridine). 

Hydrogen peroxide disproportionation with manganese macrocyclic complexes of cyclen and pyclen

David M. Freire, a   Debora Beeri, a   Kristof Pota, a   Hannah M. Johnston,a   Philip Palacios,b   Brad S. Pierce, c   Benjamin D. Sherman a  and  Kayla N. Green  *a

, Inorganic Chemistry Frontiers, Issue 7, 2020

In this work, hydrogen peroxide disproportionation using complexes formed between manganese and cyclen or pyclen were investigated due to the spectroscopic similarities with the native MnCAT enzyme.

294-90-6 Process route

C<sub>14</sub>H<sub>24</sub>N<sub>4</sub>

C14H24N4

cyclohexane-1,2-dione
765-87-7

cyclohexane-1,2-dione

1,4,7,10-tetraazacyclododecan
294-90-6

1,4,7,10-tetraazacyclododecan

Conditions
Conditions Yield
With hydrogenchloride; In water; at 60 ℃; for 6h;
 
1,4,7,10-tetraazacyclododecane tetrahydrochloride
10045-25-7

1,4,7,10-tetraazacyclododecane tetrahydrochloride

1,4,7,10-tetraazacyclododecan
294-90-6

1,4,7,10-tetraazacyclododecan

Conditions
Conditions Yield
With hydrogenchloride;
95%
With potassium hydroxide; In water; at 0 - 10 ℃;
91.3%
With potassium hydroxide;
 
With sodium hydroxide; In toluene; at 40 ℃; for 1h; Reflux;
13.77 g
With sodium hydroxide; In water; toluene;
12 g

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