Intermediate of API

143062-84-4

  • Product Name：(1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE
  • Molecular Formula：C7H8O3S.C3H6FN
  • Specifications：99%
  • Molecular Weight：247.29
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Product Details;

CasNo： 143062-84-4

Molecular Formula： C7H8O3S.C3H6FN

High Purity (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE 143062-84-4 Good Producer In Bulk Supply

  • Molecular Formula:C7H8O3S.C3H6FN
  • Molecular Weight:247.29
  • Boiling Point:418.2 °C at 760 mmHg 
  • Flash Point:206.7 °C 
  • PSA：88.77000 
  • LogP:3.07830 

143062-84-4 Relevant articles

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Paragraph 0038-0064, (2017/07/07)

The invention discloses a preparation me...

Stereoselective synthesis of cis -2-fluorocyclopropanecarboxylic acid

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, p. 7226 - 7231 (2014/08/18)

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Synthesis of cis-2-fluorocyclopropylamine by stereoselective cyclopropanation under phase-transfer conditions

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, p. 464 - 465 (2007/10/03)

cis-2-Fluorocyclopropylamine is stereose...

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, p. 3889 - 3904 (2007/10/02)

The title synthesis was achieved by empl...

143062-84-4 Process route

1,1,2-tribromo-2-fluoroethane
598-67-4

1,1,2-tribromo-2-fluoroethane

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

(1R,2S)-2-fluorocyclopropylamine p-toluenesulfonic acid salt
143062-84-4,185225-84-7

(1R,2S)-2-fluorocyclopropylamine p-toluenesulfonic acid salt

Conditions
Conditions Yield
1,1,2-tribromo-2-fluoroethane; malonic acid dimethyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 60h; Large scale;
With palladium on activated charcoal; hydrogen; In methanol; for 24h; under 3800.26 Torr; Autoclave; Large scale;
toluene-4-sulfonic acid; Temperature; Further stages; Large scale;
204 g
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

benzyl N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate

benzyl N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate

(1R*,2S*)-2-fluorocyclopropylammonium p-toluenesulfonate
143062-73-1,143062-84-4,151200-30-5,185225-84-7

(1R*,2S*)-2-fluorocyclopropylammonium p-toluenesulfonate

Conditions
Conditions Yield
With hydrogen; palladium on activated charcoal; In methanol; for 1.5h; under 760 Torr; Ambient temperature;
87%

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143062-84-4 Downstream products

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