Intermediate of API

5345-47-1

  • Product Name：2-Aminonicotinic acid
  • Molecular Formula：C6H6N2O2
  • Specifications：99%
  • Molecular Weight：138.126
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Product Details;

CasNo： 5345-47-1

Molecular Formula： C6H6N2O2

Appearance： Off-white to light yellow crystalline powder

High Purity 2-Aminonicotinic acid 5345-47-1 Crystalline Powder In Bulk Supply

  • Molecular Formula:C6H6N2O2
  • Molecular Weight:138.126
  • Appearance/Colour:Off-white to light yellow crystalline powder 
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:295-297 °C (dec.)(lit.) 
  • Refractive Index:1.649 
  • Boiling Point:342.311 °C at 760 mmHg 
  • PKA:2.94±0.10(Predicted) 
  • Flash Point:160.824 °C 
  • PSA：76.21000 
  • Density:1.417 g/cm3 
  • LogP:0.94320 

2-Aminonicotinic acid(Cas 5345-47-1) Usage

Chemical Properties

Off-white to light yellow crystalline powder

Uses

A component of hair dyes.

Photoisomerization is a fundamental process that plays an important role in chemistry and biology alike.  2-aminonicotinic acid (or 2-aminopyridine-3-carboxylic acid, abbreviated ANA) can serve as a model compound for such reactions containing both carboxylic and amino groups attached to the pyridine ring.

Definition

ChEBI: An aminonicotinic acid in which the amino group is situated at position 2 of the pyridine ring.

InChI:InChI=1/C6H6N2O2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H2,7,8)(H,9,10)

5345-47-1 Relevant articles

Synthesis, spectral studies and biological evaluation of 2-aminonicotinic acid metal complexes

Muhammad Nawaz a, Muhammad Waseem Abbasi b, Soleiman Hisaindee c, Muhammad Javed Zaki b, Hira Fatima Abbas d, Hu Mengting e, M.Arif Ahmed f

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Volume 161, 15 May 2016, Pages 39-43

We synthesized 2-aminonicotinic acid (2-ANA) complexes with metals such as Co(II), Fe(III), Ni(II), Mn(II), Zn(II), Ag(I),Cr(III), Cd(II) and Cu(II) in aqueous media. In summary, a series of metal complexes have been prepared with 2-aminonicotinic acid ligand, involving 1:1 and 1:2 metal/ligand stoichiometries.

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer

Tan, Wen-Yun,Lu, Yi,Zhao, Jing-Feng,Chen, Wen,Zhang, Hongbin

supporting information, p. 6648 - 6653 (2021/09/08)

The oxidation of primary alcohols and al...

Microwave-assisted synthesis of 2-aminonicotinic acids by reacting 2-chloronicotinic acid with amines

Camilo E. Quevedo, Vassilios Bavetsias, Edward McDonald

Tetrahedron Letters Volume 50, Issue 21, 27 May 2009, Pages 2481-2483

Subsequently, we found that a range of 2-aminonicotinic acids could be obtained under microwave heating. The optimal reaction conditions involved the use of 3 equiv of amine, water as the solvent and heating at 200 °C for 2 h in the presence of diisopropylethylamine (3 equiv).

Phototransformations of 2-aminonicotinic acid resolved with matrix isolation infrared spectroscopy and ab initio calculations

M. Pagacz-Kostrzewa a, M.A. Kochman b, W. Gul a, M. Wierzejewska a

Journal of Photochemistry and Photobiology A: Chemistry Volume 410, 1 April 2021, 113187

The two most stable amino isomers of 2-aminonicotinic acid (ANA-1 and ANA-2) were identified in low temperature argon matrices based on the spectral pattern observed in the infrared spectra of ANA/Ar after deposition.

5345-47-1 Process route

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

2-aminopyridin-3-carboxylic acid
5345-47-1

2-aminopyridin-3-carboxylic acid

Conditions
Conditions Yield
With ammonium hydroxide; L-2-O-methyl-chiro-inositol; copper(II) acetate monohydrate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 12h;
72%
2-Aminocarbonylnicotinic acid
5860-70-8

2-Aminocarbonylnicotinic acid

2-aminopyridin-3-carboxylic acid
5345-47-1

2-aminopyridin-3-carboxylic acid

Conditions
Conditions Yield
With bromine; sodium hydroxide; at 5 - 85 ℃; for 2.5h;
98.2%

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