intermediate of API

131875-08-6

  • Product Name：Lexacalcitol
  • Molecular Formula：C29H48O4
  • Specifications：99%
  • Molecular Weight：460.69
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Product Details;

CasNo： 131875-08-6

Molecular Formula： C29H48O4

Perfect Factory Offer Excellent quality Lexacalcitol 131875-08-6 with Safe Shipping

  • Molecular Formula:C29H48O4
  • Molecular Weight:460.69
  • Vapor Pressure:6.49E-17mmHg at 25°C 
  • Refractive Index:1.541 
  • Boiling Point:600.3 °C at 760 mmHg 
  • PKA:14.43±0.40(Predicted) 
  • Flash Point:316.8 °C 
  • PSA：69.92000 
  • Density:1.07 g/cm3 
  • LogP:5.86380 

Lexacalcitol(Cas 131875-08-6) Usage

General Description

Lexacalcitol is a synthetic analog of vitamin D that is primarily used for the treatment of hyperparathyroidism and secondary hyperparathyroidism in patients with chronic kidney disease. It works by binding to the vitamin D receptors in the parathyroid glands, leading to a decrease in parathyroid hormone levels and a reduction in the release of calcium and phosphorus from the bones. This helps to maintain normal levels of these minerals in the blood and prevent the development of bone disorders such as osteoporosis. Lexacalcitol is administered orally and has been shown to be effective in lowering parathyroid hormone levels and improving bone health in patients with chronic kidney disease. However, it may also cause side effects such as gastrointestinal disturbances, headaches, and skin rashes, so it should be used with caution and under the guidance of a healthcare professional.

InChI:InChI=1/C29H48O4/c1-6-29(32,7-2)16-9-17-33-21(4)25-13-14-26-22(10-8-15-28(25,26)5)11-12-23-18-24(30)19-27(31)20(23)3/h11-12,21,24-27,30-32H,3,6-10,13-19H2,1-2,4-5H3/b22-11+,23-12-/t21-,24-,25-,26+,27+,28-/m1/s1

131875-08-6 Relevant articles

Highly potent cell differentiation-inducing analogues of 1α,25-dihydroxyvitamin D3: Synthesis and biological activity of 2-methyl-1,25-dihydroxyvitamin D3 with side-chain modifications

Fujishima, Toshie,Zhaopeng, Liu,Konno, Katsuhiro,Nakagawa, Kimie,Okano, Toshio,Yamaguchi, Kentaro,Takayama, Hiroaki

, p. 525 - 535 (2007/10/03)

Eight 2-methyl substituted analogues of ...

131875-08-6 Process route

6-((R)-1-{(1S,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-ethoxy)-3-ethyl-hexan-3-ol

6-((R)-1-{(1S,3aS,7aS)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-ethoxy)-3-ethyl-hexan-3-ol

lexacalcitol
131875-08-6,154461-85-5

lexacalcitol

Conditions
Conditions Yield
With camphor-10-sulfonic acid; In methanol; at 20 ℃;
30%
4-ethyl-hexane-1,4-diol
1113-00-4

4-ethyl-hexane-1,4-diol

lexacalcitol
131875-08-6,154461-85-5

lexacalcitol

Conditions
Conditions Yield
Multi-step reaction with 9 steps
1: 96 percent / pyridine / 1 h / 0 °C
2: 2,6-lutidine / 1 h / 0 °C
3: 92 percent / NaI / dimethylformamide / 6 h / 20 °C
4: 86 percent / KH; 18-crown-6 / tetrahydrofuran / 20 °C
5: 81 percent / TFA / CH2Cl2 / 0.75 h / 0 °C
6: 80 percent / 4 Angstroem molecular sieves; PDC / CH2Cl2 / 1 h / 20 °C
7: 33 percent / NaHMDS / tetrahydrofuran / -60 - 20 °C
8: (dba)3Pd2*CHCl3; Ph3P; Et3N / toluene / 6 h / Heating
9: 30 percent / CSA / methanol / 20 °C
With 2,6-dimethylpyridine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; dipyridinium dichromate; 18-crown-6 ether; 4 A molecular sieve; camphor-10-sulfonic acid; sodium hexamethyldisilazane; potassium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1: esterification / 2: silylation / 3: substitution / 4: etherification / 5: hydrolysis / 6: oxidation / 7: Wittig reaction / 8: cyclocondensation / 9: hydrolysis;

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