Intermediate of API

57280-22-5

  • Product Name：4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane （DTCO）
  • Molecular Formula：C7H12O3
  • Specifications：99%
  • Molecular Weight：144.17
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Product Details;

CasNo： 57280-22-5

Molecular Formula： C7H12O3

High Quality Top Purity 57280-22-5 Liquid In Stock For Sale, Chinese Good Producer In Bulk Supply with Best Price

  • Molecular Formula:C7H12O3
  • Molecular Weight:144.17
  • Refractive Index:1.4560 to 1.4600 
  • Boiling Point:179℃ 
  • Flash Point:56℃ 
  • PSA：30.99000 
  • Density:1.071 
  • LogP:0.53670 

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57280-22-5 Process route

2,2-dimethyl-4,7-dihydro-1,3-dioxepin
1003-83-4

2,2-dimethyl-4,7-dihydro-1,3-dioxepin

4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane
57280-22-5

4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane

Conditions
Conditions Yield
With disodium hydrogenphosphate; dihydrogen peroxide; sodium hydroxide; In methanol; water; acetonitrile; at 60 - 80 ℃; pH=7 - 9.5; Large scale; Green chemistry;
85.2%
With disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
85%
With disodium hydrogenphosphate; dihydrogen peroxide; Hexafluoroacetone; In 1,2-dichloro-ethane; for 24h; Heating;
83%
With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
80%
With sodium hydroxide; tert-butylhypochlorite; sodium hydrogensulfite; In aqueous t-butanol;
80%
With dihydrogen peroxide; sodium carbonate; In methanol; benzonitrile;
70%
With dihydrogen peroxide; sodium carbonate; In methanol; acetonitrile;
67%
With disodium hydrogenphosphate; phosphomolybdic acid; dihydrogen peroxide; sodium hydroxide; In methanol; water; at 40 - 60 ℃; for 3h; pH=8 - 10; Reagent/catalyst;
 
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; water / tetrahydrofuran / 2 h / 20 °C
2: potassium carbonate / methanol / 16 h / 20 °C
With N-Bromosuccinimide; water; potassium carbonate; In tetrahydrofuran; methanol;
 
C<sub>7</sub>H<sub>13</sub>BrO<sub>3</sub>

C7H13BrO3

4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane
57280-22-5

4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane

Conditions
Conditions Yield
With potassium carbonate; In methanol; at 20 ℃; for 16h;
19 g

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