intermediate of API

131918-61-1

  • Product Name：Paricalcitol
  • Molecular Formula：C27H44O3
  • Specifications：99%
  • Molecular Weight：416.645
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Product Details;

CasNo： 131918-61-1

Molecular Formula： C27H44O3

Manufacturer supply high quality Paricalcitol 131918-61-1 with ISO standards

  • Molecular Formula:C27H44O3
  • Molecular Weight:416.645
  • Vapor Pressure:4.13E-15mmHg at 25°C 
  • Refractive Index:1.609 
  • Boiling Point:564.8 °C at 760 mmHg 
  • PKA:14.34±0.40(Predicted) 
  • Flash Point:238.4 °C 
  • PSA：60.69000 
  • Density:1.121 g/cm3 
  • LogP:5.56060 

Paricalcitol(Cas 131918-61-1) Usage

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

Extensively metabolised via hepatic and non-hepatic pathways to form two relatively inactive metabolites. After oral administration of 3 H-paricalcitol, only about 2% of the dose was eliminated unchanged in the faeces, and no parent drug found in the urine. Approximately 70% of the radioactivity was eliminated in the faeces and 18% was recovered in the urine. Most of the systemic exposure was from the parent drug.

Brand name

Zemplar (Abbott).

InChI:InChI=1/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1

131918-61-1 Relevant articles

Synthesis of paricalcitol: A novel strategy combining chemical and microbial transformations

Luo,Jiang,Song,Fang,Lu

, p. 323 - 327 (2017)

A novel strategy was developed for the p...

Preparation method of paracetamol and injection thereof

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Paragraph 0018; 0042; 0044-0070, (2020/08/17)

The invention provides a preparation met...

Preparation method of paricalcitol isomer impurity PY5

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, (2019/10/23)

The invention discloses a preparation me...

Purification method for paricalcitol

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, (2018/04/01)

The invention provides a purification me...

Preparation method for paricalcitol

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, (2018/04/01)

The invention discloses a preparation me...

131918-61-1 Process route

C<sub>29</sub>H<sub>46</sub>O<sub>4</sub>

C29H46O4

paricalcitol
131918-61-1

paricalcitol

Conditions
Conditions Yield
With water; sodium hydroxide; In ethanol; at 20 - 25 ℃; for 1.33333h;
89.5%
C<sub>39</sub>H<sub>72</sub>O<sub>3</sub>Si<sub>2</sub>
1192803-39-6

C39H72O3Si2

paricalcitol
131918-61-1

paricalcitol

Conditions
Conditions Yield
With 10-camphorsulfonic acid; In methanol; chloroform; at 20 ℃; for 1.5h;
57%

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