Intermediate of API

13081-18-0

  • Product Name：Ethyl trifluoropyruvate （E-TFPA）
  • Molecular Formula：C5H5F3O3
  • Specifications：99%
  • Molecular Weight：170.088
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Product Details;

CasNo： 13081-18-0

Molecular Formula： C5H5F3O3

Appearance： Yellow to pale yellow clear liquid

Chinese Factory Supply Ethyl trifluoropyruvate （E-TFPA） 13081-18-0 In Stock Best Price

  • Molecular Formula:C5H5F3O3
  • Molecular Weight:170.088
  • Appearance/Colour:Yellow to pale yellow clear liquid 
  • Vapor Pressure:208mmHg at 25°C 
  • Refractive Index:n20/D 1.341(lit.)  
  • Boiling Point:88.1 °C at 760 mmHg 
  • Flash Point:8.1 °C 
  • PSA：43.37000 
  • Density:1.328 g/cm3 
  • LogP:0.68090 

Ethyl trifluoropyruvate(Cas 13081-18-0) Usage

Chemical Properties

Clear pale yellow liquid

Uses

Ethyl Trifluoropyruvate is used as a reagent in the preparation of potential biologically active compounds such as in the highly enantioselective organocatalytic hydroxyalkylation of indoles .

General Description

Ethyl 3,3,3-trifluoropyruvate is a trifluoromethylated compound. Enantioselective Friedel–Crafts alkylation of simple phenols and indoles with ethyl 3,3,3-trifluoropyruvate under different reaction conditions have been reported.

InChI:InChI=1/C4H3F3O3/c1-10-3(9)2(8)4(5,6)7/h1H3

13081-18-0 Relevant articles

REACTIONS OF BROMORTRIFLUOROMETHANE WITH ACID DERIVATIVES IN THE PRESENCE OF ZINC.

Francese, C.,Tordeux, M.,Wakselman, C.

, p. 1029 - 1030 (1988)

Reaction of zinc with bromotrifluorometh...

Practical Processes for Producing Fluorinated alpha-Ketocarboxylic Esters and Analogues Thereof

-

Paragraph 0143; 0144; 0145; 0146; 0147; 0148; 0149; 0150, (2018/03/10)

It is possible to produce a fluorine-con...

Synthesis of fluorinated 1,2,3-butatrienes from α-halovinyl organometallic reagents

Morken,Bachand, Patrick C.,Swenson, Dale C.,Burton, Donald J.

, p. 5430 - 5439 (2007/10/02)

The thermal stability and dimerization r...

Reactions of Trifluoromethyl Bromide and Related Halides: Part 9. Comparison between Additions to Carbonyl Compounds, Enamines, and Sulphur Dioxide in the Presence of Zinc

Tordeux, Marc,Francese, Catherine,Wakselman, Claude

, p. 1951 - 1957 (2007/10/02)

A Barbier procedure, under moderate pres...

Process for the preparation of perfluoroalkyl ketones

-

, (2008/06/13)

A process for the preparation of a perfl...

13081-18-0 Process route

2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester
10186-66-0

2-fluoro-2-ethoxy-trifluoropropionic acid ethyl ester

1-fluoroethane
353-36-6

1-fluoroethane

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Conditions
Conditions Yield
antimony pentafluoride; In neat (no solvent);
83%
ethyl 3,3,3-trifluoro-2-hydroxypropanoate
94726-00-8

ethyl 3,3,3-trifluoro-2-hydroxypropanoate

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Conditions
Conditions Yield
With sodium hypochlorite pentahydrate; In acetonitrile; at 20 ℃; for 0.5h; Reagent/catalyst; Solvent;
69%

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