Intermediate of API

120014-30-4

  • Product Name：5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one HCL
  • Molecular Formula：C17H23NO3
  • Specifications：99%
  • Molecular Weight：289.375
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Product Details;

CasNo： 120014-30-4

Molecular Formula： C17H23NO3

High Grade 99% Purity 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one HCL 120014-30-4 For Sale

  • Molecular Formula:C17H23NO3
  • Molecular Weight:289.375
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:258-260°C (dec.) 
  • Refractive Index:1.538 
  • Boiling Point:454.109 °C at 760 mmHg 
  • PKA:10.57±0.10(Predicted) 
  • Flash Point:228.437 °C 
  • PSA：47.56000 
  • Density:1.116 g/cm3 
  • LogP:2.77730 

5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one(Cas 120014-30-4) Usage

Chemical Properties

Pale Yellow Solid

Uses

5,6-Dimethoxy-2-[(4-piperidyl)methyl]indan-1-one is an impurity of Donepezil (D531750), an inhibitor of acetylcholinesterase.

InChI:InChI=1/C17H23NO3/c1-20-15-9-12-8-13(7-11-3-5-18-6-4-11)17(19)14(12)10-16(15)21-2/h9-11,13,18H,3-8H2,1-2H3

120014-30-4 Relevant articles

Synthesis, molecular docking studies, and antimicrobial evaluation of new structurally diverse ureas

Patil, Mahadev,Poyil, Anurag Noonikara,Joshi, Shrinivas D.,Patil, Shivaputra A.,Patil, Siddappa A.,Bugarin, Alejandro

, p. 302 - 311 (2019)

A series of new urea derivatives (3a-p) ...

Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase

Renou, Julien,Dias, José,Mercey, Guillaume,Verdelet, Tristan,Rousseau, Catherine,Gastellier, Anne-Julie,Arboléas, Mélanie,Touvrey-Loiodice, Mélanie,Baati, Rachid,Jean, Ludovic,Nachon, Florian,Renard, Pierre-Yves

, p. 17929 - 17940 (2016)

Poisoning by organophosphorus nerve agen...

Two novel donepezil-lipoic acid hybrids: Synthesis, anticholinesterase and antioxidant activities and theoretical studies

Terra, Bruna S.,Da Silva, Pedro H. C.,Tramarin, Anna,Franco, Lucas L.,Da Cunha, Elaine F. F.,Macedo, Fernando,Ramalho, Teodorico C.,Bartolini, Manuela,Bolognesi, Maria L.,De Fátima, ?ngelo

, p. 738 - 747 (2018)

Alzheimer disease (AD) is a complex dise...

Synthesis, kinetic evaluation and molecular docking studies of donepezil-based acetylcholinesterase inhibitors

Gonzalez, Michael,Hudson, Paula K.,Lorzadeh, Shahrokh,Makarian, Makar,Pecic, Stevan,Salvador, Stephanie M.

, (2021/09/14)

In an effort to develop new therapeutic ...

Polysilane-Immobilized Rh-Pt Bimetallic Nanoparticles as Powerful Arene Hydrogenation Catalysts: Synthesis, Reactions under Batch and Flow Conditions and Reaction Mechanism

Miyamura, Hiroyuki,Suzuki, Aya,Yasukawa, Tomohiro,Kobayashi, Shu

, p. 11325 - 11334 (2018/09/06)

Hydrogenation of arenes is an important ...

120014-30-4 Process route

1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
120014-07-5,145546-80-1

1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine

donepezil
120014-06-4,142057-79-2,142057-80-5,142698-19-9

donepezil

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
Conditions Yield
With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 0 - 2 ℃; for 1.5h; under 760.051 Torr;
With hydrogen; palladium 10% on activated carbon; In toluene; at 0 - 1 ℃; for 5h; under 6000.6 - 7500.75 Torr;
2-(pyridin-4-yl)methyl-5,6-dimethoxy-1-indanone
4803-57-0

2-(pyridin-4-yl)methyl-5,6-dimethoxy-1-indanone

debenzyldonepezil
120014-30-4

debenzyldonepezil

Conditions
Conditions Yield
With hydrogen; platinum(IV) oxide; In methanol; acetic acid; at 20 ℃; for 6h; under 2311.54 Torr;
99%
With palladium on activated charcoal; hydrogen; acetic acid; In methanol;
74%
With 5% Pd(II)/C(eggshell); hydrogen; sodium acetate; acetic acid; In methanol; dichloromethane; at 70 - 75 ℃; for 10h; under 4413.43 - 5149.01 Torr;
70%

120014-30-4 Upstream products

  • 877606-65-0
    877606-65-0

    (E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one

  • 872-85-5
    872-85-5

    pyridine-4-carbaldehyde

  • 2107-69-9
    2107-69-9

    5,6-dimethoxy-1-indanone

  • 861675-47-0
    861675-47-0

    5,6-dimethoxy-2-(4-piperidinylmethyl)-indan-1-one acetate

120014-30-4 Downstream products

  • 844694-85-5
    844694-85-5

    1,1-dibenzyl-4-(5,6-dimethoxy-1-oxo-indan-2-ylmethyl)-piperidinium; bromide

  • 120014-06-4
    120014-06-4

    donepezil

  • 142057-77-0
    142057-77-0

    donepezil hydrochloride

  • 1033718-29-4
    1033718-29-4

    ethyl 3-((4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)methyl)benzoate

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