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160232-08-6

  • Product Name:tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino) propyl] carbamate
  • Molecular Formula:C19H32N2O3
  • Specifications:99%
  • Molecular Weight:336.475
Inquiry

Product Details;

CasNo: 160232-08-6

Molecular Formula: C19H32N2O3

Appearance: White solid

Factory Sells High Grade tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino) propyl] carbamate 160232-08-6 Best Price

  • Molecular Formula:C19H32N2O3
  • Molecular Weight:336.475
  • Appearance/Colour:White solid 
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:145 °C 
  • Refractive Index:1.512 
  • Boiling Point:484.697 °C at 760 mmHg 
  • PKA:12.07±0.46(Predicted) 
  • Flash Point:246.936 °C 
  • PSA:70.59000 
  • Density:1.04 g/cm3 
  • LogP:3.51070 

tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate(Cas 160232-08-6) Usage

Chemical Properties

White Solid

Uses tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate (cas# 160232-08-6) is a compound useful in organic synthesis.

Isomeric SMILES: CC(C)CNC[C@H]([C@H](CC1=CC=CC=C1)NC(=O)OC(C)(C)C)O  
InChIKey: NVEPLQDORJSXRO-DLBZAZTESA-N  
InChI: InChI=1S/C19H32N2O3/c1-14(2)12-20-13-17(22)16(11-15-9-7-6-8-10-15)21-18(23)24-19(3,4)5/h6-10,14,16-17,20,22H,11-13H2,1-5H3,(H,21,23)/t16-,17+/m0/s1  

160232-08-6 Relevant articles

A facile synthesis of (2R,3S)-1-amino-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutane; A useful component block of HIV protease inhibitor

Yuasa, Yoko,Yuasa, Yoshifumi,Tsuruta, Haruki

, p. 395 - 401 (1998)

(S)-3-tert-Butoxycarbonylamino-1-nitro-2...

An improved and robust scale-up process aided with identification and control of critical process impurities in darunavir ethanolate

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, p. 267 - 281 (2020)

A robust and safe industrial process, in...

Design and evaluation of novel piperidine HIV-1 protease inhibitors with potency against DRV-resistant variants

Zhu, Mei,Zhou, Huiyu,Ma, Ling,Dong, Biao,Zhou, Jinming,Zhang, Guoning,Wang, Minghua,Wang, Juxian,Cen, Shan,Wang, Yucheng

, (2021/06/02)

A novel class of HIV-1 protease inhibito...

Design and biological evaluation of cinnamic and phenylpropionic amide derivatives as novel dual inhibitors of HIV-1 protease and reverse transcriptase

Zhu, Mei,Shan, Qi,Ma, Ling,Wen, Jiajia,Dong, Biao,Zhang, Guoning,Wang, Minghua,Wang, Juxian,Zhou, Jinming,Cen, Shan,Wang, Yucheng

, (2021/05/04)

Upon the basis of both possible ligand-b...

Ionization methods in organic mass spectrometry

AE Ashcroft

, Book 1997

For example, the formulae C21H36O3 and C19H32N2O3 (tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino) propyl] carbamate) have monoisotopic masses of 336.2664 and 336.2413, respectively.

160232-08-6 Process route

isobutylamine
78-81-9

isobutylamine

tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
165727-45-7

tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate

(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
160232-08-6

(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol

Conditions
Conditions Yield
With potassium hydroxide; In ethanol; at 15 - 20 ℃; Large scale;
97.3%
With sodium carbonate; In water; at 60 - 65 ℃; for 3h;
105 g
With sodium carbonate; In water; at 60 - 65 ℃; for 3h;
105 g
isobutylamine
78-81-9

isobutylamine

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
160232-08-6

(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol

Conditions
Conditions Yield
In isopropyl alcohol; at 20 ℃;
100%
In isopropyl alcohol; at 60 ℃; for 6h;
100%
In isopropyl alcohol; at 60 ℃; Inert atmosphere;
100%
In isopropyl alcohol; for 6h; Heating;
99%
In ethanol; at 78 ℃; for 1h; Inert atmosphere;
99.8%
In isopropyl alcohol; at 90 ℃; for 72h;
99%
In isopropyl alcohol; at 80 ℃; for 3h;
97%
at 65 - 75 ℃; for 3h;
97.63%
at 65 - 70 ℃;
97.87%
In neat (no solvent); at 50 - 60 ℃; for 2h; Solvent; Reflux;
95.7%
In ethanol; at 20 - 80 ℃; for 3h; Inert atmosphere;
91%
In acetonitrile; for 6h; Reflux;
91.5%
In acetonitrile; for 6h; Reflux;
91.5%
In isopropyl alcohol; at 50 ℃; for 5h;
90%
In ethanol; at 80 ℃; for 3h;
85%
In acetonitrile; at 80 ℃; for 5h;
83%
In acetonitrile; at 80 ℃; for 5h;
83%
In acetonitrile; at 80 ℃; for 5h;
83%
In acetonitrile; at 80 ℃; for 6h; Inert atmosphere; Sealed tube;
83%
In acetonitrile; at 80 ℃; for 6h;
83%
In isopropyl alcohol; at 68 ℃; for 3.5h;
 
In isopropyl alcohol; for 16h; Heating;
 
In dichloromethane;
 
In isopropyl alcohol; at 60 ℃;
 
In isopropyl alcohol;
 
In isopropyl alcohol; at 80 ℃; for 2h;
 
In ethanol; at 80 ℃; for 3h;
 
In ethanol; at 50 ℃;
 
Heating / reflux;
 
 
 
at 80 ℃;
 
In ethanol; at 80 ℃; for 3h;
 
In isopropyl alcohol; for 1h; Heating / reflux;
 
In ethanol; at 80 ℃; for 3h; Inert atmosphere;
 
In methanol; for 3h; Reflux;
 
In dichloromethane; for 3h; Reflux;
 
at 70 - 75 ℃; for 3h;
231 g
at 70 - 75 ℃; for 3h;
231 g
In ethanol; at 80 ℃; for 3h;
 
In isopropyl alcohol;
 
In isopropyl alcohol; at 80 ℃; for 3h;
 
In acetonitrile; at 80 ℃; for 6h;
 
In acetonitrile; at 80 ℃; for 6h; Inert atmosphere;
 

160232-08-6 Upstream products

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    C19H31N3O4

  • 78-84-2
    78-84-2

    isobutyraldehyde

  • 162536-42-7
    162536-42-7

    (1S,2R)-(3-amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert butyl ester

  • 78-81-9
    78-81-9

    isobutylamine

160232-08-6 Downstream products

  • 159006-03-8
    159006-03-8

    tert-butyl (1S,2R)-1-benzyl-2-hydroxy-3-{isobutyl[(4-methoxyphenyl)sulfonyl]amino}propylcarbamate

  • 191226-98-9
    191226-98-9

    [(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

  • 733742-54-6
    733742-54-6

    (S)-2-[3-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-3-isobutyl-ureido]-4-methyl-pentanoic acid methyl ester

  • 553644-88-5
    553644-88-5

    tert-butyl ((2S,3R)-4-((4-acetyl-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate

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