Intermediate of API

82911-69-1

  • Product Name：Fmoc-Osu
  • Molecular Formula：C19H15NO5
  • Specifications：99%
  • Molecular Weight：337.332
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Product Details;

CasNo： 82911-69-1

Molecular Formula： C19H15NO5

Appearance： White powder

Factory Supply Pharmaceutical Intermediates Fmoc-Osu 82911-69-1 Good Price

  • Molecular Formula:C19H15NO5
  • Molecular Weight:337.332
  • Appearance/Colour:White powder 
  • Vapor Pressure:6.55E-10mmHg at 25°C 
  • Melting Point:150-153 °C(lit.) 
  • Refractive Index:1.661 
  • Boiling Point:494.3 °C at 760 mmHg 
  • Flash Point:252.7 °C 
  • PSA：72.91000 
  • Density:1.42 g/cm3 
  • LogP:2.95400 

N-(9-Fluorenylmethoxycarbonyloxy)succinimide(Cas 82911-69-1) Usage

Chemical Properties

White powder

Uses

N-(9-Fluorenylmethoxycarbonyloxy)succinimide is used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.

Purification Methods

Recrystallise the carbonate from CHCl3/Et2O, or from pet ether (b 40-60o). [Pauet Can J Chem 60 976 1982, Lapatsaris et al. Synthesis 671 1983.]

InChI:InChI=1/C19H15NO5/c21-17-9-10-18(22)20(17)25-19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2

82911-69-1 Relevant articles

Method for synthesizing 9-fluorenylmethylsuccinimido carbonate by one-pot two-phase method

-

Paragraph 0011; 0024-0029, (2020/03/03)

The invention relates to the technical f...

Eight-membered ring-containing jadomycins: Implications for non-enzymatic natural products biosynthesis

Robertson, Andrew W.,Martinez-Farina, Camilo F.,Smithen, Deborah A.,Yin, Huimin,Monro, Susan,Thompson, Alison,McFarland, Sherri A.,Syvitski, Raymond T.,Jakeman, David L.

supporting information, p. 3271 - 3275 (2015/03/30)

Jadomycin Oct (1) was isolated from Stre...

The two pathways for effective orthogonal protection of L-ornithine, for amino acylation of 5'-O-Pivaloyl nucleosides, describe the general and important role for the successful imitation, during the synthesis of the model substrates for the ribosomal mimic reaction

Bayryamov, Stanislav G.,Vassilev, Nikolay G.,Petkov, Dimiter D.

experimental part, p. 889 - 898 (2011/12/14)

Bz(NO2)-Orn(Boc)-OCH2CN was synthesized ...

The study of the reaction of terminated oligomerization in the synthesis of oligo-(β1-6)-glucosamines

Gening,Tsvetkov,Pier,Nifantiev

, p. 389 - 399 (2008/02/09)

The applicability of terminated oligomer...

82911-69-1 Process route

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Conditions
Conditions Yield
With triethylamine; In 1,4-dioxane; for 1h; Ambient temperature;
96%
With sodium carbonate; In water; toluene; at 25 - 30 ℃; for 2h; Reagent/catalyst; Solvent;
56.3%
With sodium carbonate; In water; acetone; for 0.5h;
With sodium carbonate; In water; acetone; at -10 ℃; for 1.5h;
With triethylamine; In 1,4-dioxane;
With diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
2,5-dioxopyrrolidin-1-yl carbonochloridate
15149-73-2

2,5-dioxopyrrolidin-1-yl carbonochloridate

9-Fluorenylmethanol
24324-17-2

9-Fluorenylmethanol

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Conditions
Conditions Yield
With pyridine; In dichloromethane; for 5h; Ambient temperature;
72%

82911-69-1 Upstream products

  • 6066-82-6
    6066-82-6

    1-hydroxy-pyrrolidine-2,5-dione

  • 28920-43-6
    28920-43-6

    (fluorenylmethoxy)carbonyl chloride

  • 15149-73-2
    15149-73-2

    2,5-dioxopyrrolidin-1-yl carbonochloridate

  • 24324-17-2
    24324-17-2

    9-Fluorenylmethanol

82911-69-1 Downstream products

  • 35661-39-3
    35661-39-3

    N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

  • 68858-20-8
    68858-20-8

    Fmoc-Val-OH

  • 73724-45-5
    73724-45-5

    N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

  • 73731-37-0
    73731-37-0

    Fmoc-Thr-OH

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