Intermediate of API

28229-69-8

  • Product Name：m-bromobenzeneethanol
  • Molecular Formula：C8H9BrO
  • Specifications：99%
  • Molecular Weight：201.063
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Product Details;

CasNo： 28229-69-8

Molecular Formula： C8H9BrO

High Purity m-bromobenzeneethanol 28229-69-8 with Good Price, Fast Delivery

  • Molecular Formula:C8H9BrO
  • Molecular Weight:201.063
  • Vapor Pressure:0.00259mmHg at 25°C 
  • Refractive Index:n20/D 1.5732(lit.)  
  • Boiling Point:274.614 °C at 760 mmHg 
  • PKA:14.83±0.10(Predicted) 
  • Flash Point:119.883 °C 
  • PSA：20.23000 
  • Density:1.479 g/cm3 
  • LogP:1.98390 

m-bromobenzeneethanol(Cas 28229-69-8) Usage

Chemical Properties

clear colorless liquid

Uses

m-Bromobenzeneethanol may be used as a starting material in the synthesis of its mesylate derivative (m-Br-C6H4CH2CH2OMs) by treatment with mesyl chloride. m-Bromobenzeneethanol finds applications in various fields, including organic synthesis and pharmaceutical research. It can serve as a starting material or intermediate for the synthesis of other organic compounds. The presence of the bromine atom makes it useful for reactions involving nucleophilic substitution or coupling reactions. Additionally, the alcohol group provides potential for further chemical modifications or functionalization.

General Description

m-Bromobenzeneethanol, also known as 3-bromo-phenethyl alcohol, i is a phenethyl alcohol derivative. Its enthalpy of vaporization at boiling point has been determined.

IUPAC Name: 2-(3-bromophenyl)ethanol  
Isomeric SMILES: C1=CC(=CC(=C1)Br)CCO  
InChIKey: PTTFLKHCSZSFOL-UHFFFAOYSA-N  
InChI: InChI=1S/C8H9BrO/c9-8-3-1-2-7(6-8)4-5-10/h1-3,6,10H,4-5H2  

28229-69-8 Relevant articles

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Blanckaert,Burvenich,Devos,Slegers

, p. 183 - 188 (2007)

This work reports the synthesis, radiola...

Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow

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Cheap and readily available aqueous form...

Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety

Xie, Jin,Yang, Fengzhi,Zhang, Man,Lam, Celine,Qiao, Yixue,Xiao, Jia,Zhang, Dongdong,Ge, Yuxuan,Fu, Lei,Xie, Dongsheng

, p. 131 - 134 (2016/12/27)

A series of CAPE derivatives with mono-s...

Photochemistry of acyloximes: Synthesis of heterocycles and natural products

Rafael Alonso, Alegría Caballero, Pedro J. Campos, Miguel A. Rodríguez

, Tetrahedron Volume 66, Issue 46, 13 November 2010, Pages 8828-8831

The hydroxy group of commercial 3-bromophenethyl alcohol was protected by reaction with tert-butyl(chloro)dimethylsilane (TBDMS-Cl) and treated with trimethyl borate and t-BuLi to …

28229-69-8 Process route

3-Bromophenylacetic acid
1878-67-7

3-Bromophenylacetic acid

2-(3-bromophenyl)ethan-1-ol
28229-69-8

2-(3-bromophenyl)ethan-1-ol

Conditions
Conditions Yield
With borane-THF; In tetrahydrofuran; at 0 ℃; for 4h;
93%
With borohydride-tetrahydrofuran complex; at 20 ℃; for 2h;
80%
3-Bromophenylacetic acid; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 20h;
With water; In tetrahydrofuran;
79%
With borane; In tetrahydrofuran; 1.) 0 deg C, 30 min, 2.) 25 deg C, 2 h;
 
With dimethylsulfide borane complex;
 
With diborane; In tetrahydrofuran; at 20 ℃; for 16h;
9.0 g
3-Bromophenylacetic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Heating / reflux;
With water; Rochelle's salt; In tetrahydrofuran;
 
With benzophenone; potassium; In tetrahydrofuran; methanol;
 
In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;
 
3-Bromophenylacetic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Heating / reflux;
With Rochelle's salt; In tetrahydrofuran; water; for 0.5h;
 
With lithium aluminium tetrahydride; In diethyl ether; Reflux;
 
3-Bromophenylacetic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
With water; In tetrahydrofuran;
 
With dimethylsulfide borane complex; In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;
 
With borane-THF; In tetrahydrofuran; at 20 ℃;
 
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;
 
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 4.5h; Reflux;
 
With diborane; In tetrahydrofuran;
 
2-(3-bromophenyl)acetaldehyde
109347-40-2

2-(3-bromophenyl)acetaldehyde

2-(3-bromophenyl)ethan-1-ol
28229-69-8

2-(3-bromophenyl)ethan-1-ol

Conditions
Conditions Yield
With sodium tetrahydroborate; In ethanol; for 1h; Inert atmosphere;
66%
With glycerol; In dimethyl sulfoxide; at 0 ℃; for 0.5h; Inert atmosphere;
 

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