Intermediate of API

20826-04-4

  • Product Name：5-Bromonicotinic acid
  • Molecular Formula：C6H4BrNO2
  • Specifications：99%
  • Molecular Weight：202.007
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Product Details;

CasNo： 20826-04-4

Molecular Formula： C6H4BrNO2

Appearance： Light yellow cryst.

High Purity 5-Bromonicotinic acid 20826-04-4 White Powder For Sale

  • Molecular Formula:C6H4BrNO2
  • Molecular Weight:202.007
  • Appearance/Colour:Light yellow cryst. 
  • Vapor Pressure:7.59E-05mmHg at 25°C 
  • Melting Point:178-180 °C(lit.) 
  • Refractive Index:1.6120 (estimate) 
  • Boiling Point:328.535 °C at 760 mmHg 
  • PKA:3.08±0.10(Predicted) 
  • Flash Point:152.5 °C 
  • PSA：50.19000 
  • Density:1.814 g/cm3 
  • LogP:1.54230 

5-Bromonicotinic acid(Cas 20826-04-4) Usage

Chemical Properties

Light yellow Cryst

Uses

5-Bromopyridine-3-carboxylic acid (5-bromonicotinic acid) was used in the synthesis of 3-guanidinomethyl-5-iodopyridine.

Purification Methods

The acid is recrystallised from H2O and then from EtOH using charcoal. The amide has m 219-219.5o (from aqueous EtOH), and the methyl ester, prepared by addition of ethereal diazomethane, can be purified by sublimation in a vacuum and has m 98-99o. The acid chloride also can be sublimed in vacuo and has m 74-75o and gives the methyl ester in MeOH. [Graf J Prakt Chem 138 244 1933, Bachman & Micucci J Am Chem Soc 70 2381 1948, Garcia et al. J Am Chem Soc 82 4430 1960, Misic-Vokovic et al. J Chem Soc 34 1978, Beilstein 22/2 V 181.]

IUPAC Name: 5-bromopyridine-3-carboxylic acid  
Isomeric SMILES: C1=C(C=NC=C1Br)C(=O)O  
InChIKey: FQIUCPGDKPXSLL-UHFFFAOYSA-N  
InChI: InChI=1S/C6H4BrNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,(H,9,10)  

20826-04-4 Relevant articles

Multifunctional coordination compounds based on lanthanide ions and 5-bromonicotinic acid: magnetic, luminescence and anti-cancer properties†

Check for updates Cristina Ruiz,a   Antonio A. García-Valdivia, a   Belén Fernández,b   Javier Cepeda, c   Itziar Oyarzabal, cg   Elisa Abas,d   Mariano Laguna,d   Jose Angel García,e   Ignacio Fernández, f   Eider San Sebastian  *c  and  Antonio Rodríguez-Diéguez *a

, CrystEngComm, Issue 25, 2019

We report the formation of four novel multifunctional coordination compounds based on 5-bromonicotinic acid and different lanthanide(III) ions (Dy, Tb, Yb and Nd), synthesized by simple hydrothermal routes.

Drug-protein conjugates: Haptenation of 1-methyl-10α- methoxydihydrolysergol and 5-bromonicotinic acid to albumin for the production of epitope-specific monoclonal antibodies against nicergoline

Gabor,Hamilton,Pittner

, p. 1120 - 1125 (1995)

Two types of monoclonal antibodies were ...

INHIBITORS OF MYOCARDIN-RELATED TRANSCRIPTION FACTOR AND SERUM RESPONSE FACTOR (MRTF/SRF)-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME

-

Paragraph 00198, (2016/06/01)

Disclosed herein are inhibitors of gene ...

Novel metal–organic frameworks based on 5-bromonicotinic acid: Multifunctional materials with H2purification capabilities

Antonio J. Calahorro,a   Marta E. López-Viseras,a   Alfonso Salinas-Castillo,b   David Fairen-Jimenez,†*c   Enrique Colacio,a   Joan Canod  and  Antonio Rodríguez-Diéguez*a

CrystEngComm, Issue 20, 2012

Two new metal–organic frameworks based on 5-bromonicotinic acid complexes [Cd(5-BrNic)2]n (1) and [Co(5-BrNic)2(H2O)]n (2) have been synthesized by hydrothermal reactions of this ligand with cadmium and cobalt metallic(II) salts in the presence of water.

20826-04-4 Process route

5-bromo-3-pyridine carboxylic acid methyl ester
29681-44-5

5-bromo-3-pyridine carboxylic acid methyl ester

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
Conditions Yield
With potassium hydroxide; In methanol; water; for 12h; Ambient temperature;
91%
With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.166667h;
33%
3-pyridinecarbonyl chloride
10400-19-8

3-pyridinecarbonyl chloride

5-bromo-3-pyridinecarboxylic acid
20826-04-4

5-bromo-3-pyridinecarboxylic acid

Conditions
Conditions Yield
With bromine; at 0 - 155 ℃; for 10h;
94%

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