Intermediate of API

156-41-2

  • Product Name：4-Chlorophenethylamine
  • Molecular Formula：C8H10ClN
  • Specifications：99%
  • Molecular Weight：155.627
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Product Details;

CasNo： 156-41-2

Molecular Formula： C8H10ClN

Appearance： clear almost colorless liquid.

High Quality 4-Chlorophenethylamine 156-41-2 with Best Price and Fast Delivery

  • Molecular Formula:C8H10ClN
  • Molecular Weight:155.627
  • Appearance/Colour:clear almost colorless liquid. 
  • Vapor Pressure:0.056mmHg at 25°C 
  • Refractive Index:n20/D 1.548(lit.)  
  • Boiling Point:233.4 °C at 760 mmHg 
  • PKA:9.72±0.10(Predicted) 
  • Flash Point:107.5 °C 
  • PSA：26.02000 
  • Density:1.128 g/cm3 
  • LogP:2.54150 

4-Chlorophenethylamine(Cas 156-41-2) Usage

Chemical Properties

Dark Solid

Uses

4-chlorophenethylamine has been used as a reactant in the preparation of isoalloxazine derivatives as cholinesterase inhibitors with a potential use in Alzheimer therapy. 4-chlorophenethylamine is commercially available.

IUPAC Name: 2-(4-chlorophenyl)ethanamine  
Isomeric SMILES: C1=CC(=CC=C1CCN)Cl  
InChIKey: SRXFXCKTIGELTI-UHFFFAOYSA-N  
InChI: InChI=1S/C8H10ClN/c9-8-3-1-7(2-4-8)5-6-10/h1-4H,5-6,10H2  

156-41-2 Relevant articles

Synthetic procedure for modifying the amine part of carpropamid: Changing 4-chlorophenethylamine to alkyl, alicyclic, and substituted phenylalkylamines

Shinzo Kagabu, Satomi Oshima, Yoshio Kurahashi, Isamu Yamaguchi

, Journal of Pesticide Science, 2007

Compounds of the 4-chlorophenethyl amine part of carpropamid were replaced with alkyl, cycloalkyl and substituted phenylalkyl amines. The amines were obtained from the corresponding ketoximes using a reduction system of sodium borohydride with molybdenum oxide as the additive.

Bi-enzymatic Conversion of Cinnamic Acids to 2-Arylethylamines

Weise, Nicholas J.,Thapa, Prasansa,Ahmed, Syed T.,Heath, Rachel S.,Parmeggiani, Fabio,Turner, Nicholas J.,Flitsch, Sabine L.

, p. 995 - 998 (2020/01/21)

The conversion of carboxylic acids, such...

Enantioselective Sequential-Flow Synthesis of Baclofen Precursor via Asymmetric 1,4-Addition and Chemoselective Hydrogenation on Platinum/Carbon/Calcium Phosphate Composites

Furiya, Yuichi,Ishitani, Haruro,Kobayashi, Shu

supporting information, (2020/05/05)

Continuous-flow synthesis of baclofen pr...

Inhibition of monoamine oxidase action on kynuramine by substrate amines and stereoisomeric α-methyl amines

RW Fuller, CP Walters

Biochemical Pharmacology, 1965

The α-methyl analogues of dopamine, norepinephrine, phenethylamine, tyramine, or 4-chlorophenethylamine also inhibited kynuramine oxidation.

156-41-2 Process route

phenethylamine
64-04-0

phenethylamine

2-(2-chlorophenyl)ethanamine
13078-80-3

2-(2-chlorophenyl)ethanamine

4-chlorophenylethylamine
156-41-2

4-chlorophenylethylamine

Conditions
Conditions Yield
With chlorine; In tetrachloromethane; at 25 ℃; Further Variations:; Solvents; Product distribution;
 
dimethylenecyclourethane
497-25-6

dimethylenecyclourethane

chlorobenzene
108-90-7

chlorobenzene

2-(2-chlorophenyl)ethanamine
13078-80-3

2-(2-chlorophenyl)ethanamine

4-chlorophenylethylamine
156-41-2

4-chlorophenylethylamine

Conditions
Conditions Yield
With aluminium trichloride; for 12h; Yield given. Title compound not separated from byproducts; Heating; 2 equivalents of AlCl3;
 

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