Intermediate of API

13078-79-0

  • Product Name：2-(3-Chlorophenyl)ethylamine
  • Molecular Formula：C8H10ClN
  • Specifications：99%
  • Molecular Weight：155.627
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Product Details;

CasNo： 13078-79-0

Molecular Formula： C8H10ClN

Appearance： clear light yellow liquid

High Purity 2-(3-Chlorophenyl)ethylamine 13078-79-0 Liquid In Stock

  • Molecular Formula:C8H10ClN
  • Molecular Weight:155.627
  • Appearance/Colour:clear light yellow liquid 
  • Vapor Pressure:0.056mmHg at 25°C 
  • Refractive Index:n20/D 1.549(lit.)  
  • Boiling Point:233.392 °C at 760 mmHg 
  • PKA:9.65±0.10(Predicted) 
  • Flash Point:107.5 °C 
  • PSA：26.02000 
  • Density:1.129 g/cm3 
  • LogP:2.54150 

2-(3-Chlorophenyl)ethylamine(Cas 13078-79-0) Usage

Chemical Properties

clear light yellow liquid

Uses

2-(3-Chlorophenyl)ethylamine has been used as a reactant in the synthesis of novel Fyn inhibitors as agents against tauopathies and tumors. This compound is commonly used in the pharmaceutical industry as a precursor for the synthesis of various drugs, including antidepressants and antipsychotics. It is also used as a research chemical in the study of neurotransmitters and their receptors in the brain.

InChI:InChI=1/C8H10ClN/c9-8-3-1-2-7(6-8)4-5-10/h1-3,6H,4-5,10H2/p+1

13078-79-0 Relevant articles

Bi-enzymatic Conversion of Cinnamic Acids to 2-Arylethylamines

Weise, Nicholas J.,Thapa, Prasansa,Ahmed, Syed T.,Heath, Rachel S.,Parmeggiani, Fabio,Turner, Nicholas J.,Flitsch, Sabine L.

, p. 995 - 998 (2020)

The conversion of carboxylic acids, such...

Synthesis of 2-(3-chlorophenyl)ethanamine and its derivatives as potential antidepressant agents.

Han, Y., et al.

Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 12, 2007, pp. 3411-3414.

The synthesized compounds were then evaluated for their ability to inhibit the reuptake of serotonin, norepinephrine, and dopamine, which are neurotransmitters implicated in depression.

Biocatalytic Formal Anti-Markovnikov Hydroamination and Hydration of Aryl Alkenes

Wu, Shuke,Liu, Ji,Li, Zhi

, p. 5225 - 5233 (2017/08/17)

Biocatalytic anti-Markovnikov alkene hyd...

Design, synthesis and biological evaluation of novel 2-(3-chlorophenyl)ethanamine derivatives as potential antipsychotic agents.

Wang, J., et al.

, Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 8, 2015, pp. 1736-1740.

The synthesized compounds were then evaluated for their ability to bind to dopamine and serotonin receptors and their ability to inhibit the activity of these receptors. The study suggests that 2-(3-chlorophenyl)ethanamine derivatives have potential as a starting point for the development of novel antipsychotic agents.

13078-79-0 Process route

3-chloro-benzeneacetonitrile
1529-41-5

3-chloro-benzeneacetonitrile

2-(3-chlorophenyl)ethylamine
13078-79-0

2-(3-chlorophenyl)ethylamine

Conditions
Conditions Yield
With potassium borohydride; copper dichloride; In water; isopropyl alcohol; at 60 ℃; for 7h;
78%
With sodium tetrahydroborate; tin(IV) chloride;
 
3-Chlorostyrene
2039-85-2,26100-04-9

3-Chlorostyrene

2-(3-chlorophenyl)ethylamine
13078-79-0

2-(3-chlorophenyl)ethylamine

Conditions
Conditions Yield
With D-Glucose; ammonia; oxygen; In aq. phosphate buffer; at 30 ℃; for 24h; regioselective reaction; Green chemistry;
 
Multi-step reaction with 3 steps
1: oxygen; styrene monooxygenase / Enzymatic reaction
2: styrene oxide isomerase / Enzymatic reaction
3: ammonia; ω-transaminase; L-alanine dehydrogenase / Enzymatic reaction
With styrene monooxygenase; L-alanine dehydrogenase; ω-transaminase; styrene oxide isomerase; ammonia; oxygen;
 

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