
CasNo: 105-53-3
Molecular Formula: C7H12O4
Appearance: colourless liquid
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Diethyl malonate is colourless liquid, while it's Molecular Formula is C7H12O4. Diethyl malonate is used in organic synthesis for the preparation of alpha-aryl malonates, mono-substituted and di-substituted acetic acid, barbiturates and artificial flavorings. It is also involved in the synthesis of pharmaceuticals like chloroquine, butazolidin and barbital. It acts as intermediate in the synthesis of vitamin B1, vitamin B6, non-steroidal anti-inflammatory agents agrochemicals and perfumes. In Knoevenagel condensation reaction, it reacts with benzaldehyde to get diethyl benzylidenemalonate.
The CAS number of Diethyl malonate is 105-53-3.
More information of Diethyl malonate 105-53-3 are:
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Synonyms |
Diethyl propanedioate;Propanedioic acid, diethyl ester;Carbethoxyacetic ester;Dicarbethoxymethane;Methanedicarboxylic acid, diethyl ester;Malonic ester;Malonic acid, diethyl ester;Ethyl Malonate;Propanedioic acid, 1,3-diethyl ester; |
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CAS Number |
105-53-3 |
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Molecular Formula |
C7H12O4 |
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Molecular Weight |
160.17 |
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Density |
1.06 g/cm3 |
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Melting Point |
-50 °C |
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Boiling Point |
199.3 °C at 760 mmHg |
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Flash Point |
100 °C |
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HS CODE |
29171910 |
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PSA |
52.60000 |
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LogP |
0.50270 |
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Pka |
13.5(at 25℃) |
Diethyl malonate is a diester derivative of malonic acid, a dicarboxylic acid with two carboxyl groups (-COO-) separated by one methylene group (-CH2-). Diethyl malonate is formed by the replacement of the hydroxyl groups (-OH) of malonic acid with ethoxy groups (-OCH2CH3). The hydrogen atoms on the methylene carbon between the two carboxyl groups make Diethyl malonate acidic. Because of its unique structure, diethyl malonate is reactive and functions as a reagent for organic synthesis and to make products such as barbiturates, pigments, and agrochemicals. Volatile esters are known to have fruity scents and are often used as fragrances and flavorings. Diethyl malonate is a volatile diester that occurs naturally in fruits such as grapes, strawberries, guava, melon, pineapple, and blackberries.
InChI:InChI:1S/C7H12O4/c1-3-10-6(8)5-7(9)11-4-2/h3-5H2,1-2H3
Articles related to Diethyl malonate:
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Article |
Source |
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Bak,Led , p. 22,23,25 (1968) |
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Noyes , p. 1105 (1896) |
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