Intermediate of API

74124-79-1

  • Product Name:N,N'-Disuccinimidyl Carbonate(DSC)
  • Molecular Formula:C9H8N2O7
  • Specifications:99%
  • Molecular Weight:256.172
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Product Details;

CasNo: 74124-79-1

Molecular Formula: C9H8N2O7

Appearance: white to slightly yellow crystalline powder

Top Purity N,N'-Disuccinimidyl Carbonate(DSC) 74124-79-1 Best Price Chinese Good Producer

  • Molecular Formula:C9H8N2O7
  • Molecular Weight:256.172
  • Appearance/Colour:white to slightly yellow crystalline powder 
  • Melting Point:190 °C 
  • Refractive Index:1.5600 (estimate) 
  • Boiling Point:383.7 °C at 760 mmHg 
  • Flash Point:185.9 °C 
  • PSA:110.29000 
  • Density:1.69 g/cm3 
  • LogP:-0.85660 

N,N'-Disuccinimidyl carbonate(Cas 74124-79-1) Usage

Chemical Properties

N,N'-Disuccinimidyl carbonate is white to slightly yellow crystalline powder

Uses

N,N’Disuccinimidyl Carbonate is a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of lig ands to proteins. The coupling reagent property of N,N’Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.

Synthesis Reference(s)

Tetrahedron Letters, 20, p. 4745, 1979 DOI: 10.1016/S0040-4039(01)86699-5

General Description

N,N′-Disuccinimidyl carbonate is used for the HPLC determination of amino compounds.

74124-79-1 Relevant articles

Improved synthesis of N,N′-disuccinimidyl carbonate using α-pinene as acid scavenger

Prasad, Maddipati,Nowshuddin, Shaik,Rao

, p. 3119 - 3121 (2005)

An improved synthesis of N,N′-disuccinim...

A convenient large scale synthesis of N,N'-disuccinimidyl carbonate

Pereira, David,Hai, Ton That,Nelson, Deanna

, p. 4019 - 4024 (1998)

An improved method for the large scale p...

Production and cogeneration N [...] succinimide, N '-di-succinimide-based carbon ester method

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Paragraph 0036-0041, (2017/02/09)

The invention belongs to the field of fi...

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, (2008/06/13)

Modified enzymes are prepared for use in...

Modified polypeptide

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, (2008/06/13)

The present invention relates to polypep...

74124-79-1 Process route

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

9-fluorenylmethyl N-succinimidyl carbonate
102774-86-7

9-fluorenylmethyl N-succinimidyl carbonate

Conditions
Conditions Yield
With tributyl-amine; In tetrahydrofuran; at -2 - 5 ℃; Temperature; Large scale;
95 kg
119 kg
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In dichloromethane; 1.) 0 deg C, 3 h, 2.) 0-20 deg C, 6 h, 3.) reflux, 2 h;
94%
With tributyl-amine; In tetrahydrofuran; for 14h; Ambient temperature;
89%
With Pinene; In tetrahydrofuran; for 12h; Heating;
76%

74124-79-1 Upstream products

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    6066-82-6

    1-hydroxy-pyrrolidine-2,5-dione

  • 32315-10-9
    32315-10-9

    bis(trichloromethyl) carbonate

  • 503-38-8
    503-38-8

    trichloromethyl chloroformate

  • 28920-43-6
    28920-43-6

    (fluorenylmethoxy)carbonyl chloride

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