CasNo: 74124-79-1
Molecular Formula: C9H8N2O7
Appearance: white to slightly yellow crystalline powder
Chemical Properties |
N,N'-Disuccinimidyl carbonate is white to slightly yellow crystalline powder |
Uses |
N,N’Disuccinimidyl Carbonate is a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of lig ands to proteins. The coupling reagent property of N,N’Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity. |
Synthesis Reference(s) |
Tetrahedron Letters, 20, p. 4745, 1979 DOI: 10.1016/S0040-4039(01)86699-5 |
General Description |
N,N′-Disuccinimidyl carbonate is used for the HPLC determination of amino compounds. |
An improved synthesis of N,N′-disuccinim...
An improved method for the large scale p...
The invention belongs to the field of fi...
Modified enzymes are prepared for use in...
The present invention relates to polypep...
1-hydroxy-pyrrolidine-2,5-dione
(fluorenylmethoxy)carbonyl chloride
di(succinimido) carbonate
9-fluorenylmethyl N-succinimidyl carbonate
Conditions | Yield |
---|---|
With
tributyl-amine;
In
tetrahydrofuran;
at -2 - 5 ℃;
Temperature;
Large scale;
|
95 kg 119 kg |
1-hydroxy-pyrrolidine-2,5-dione
bis(trichloromethyl) carbonate
di(succinimido) carbonate
Conditions | Yield |
---|---|
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
1.) 0 deg C, 3 h, 2.) 0-20 deg C, 6 h, 3.) reflux, 2 h;
|
94% |
With
tributyl-amine;
In
tetrahydrofuran;
for 14h;
Ambient temperature;
|
89% |
With
Pinene;
In
tetrahydrofuran;
for 12h;
Heating;
|
76% |
1-hydroxy-pyrrolidine-2,5-dione
bis(trichloromethyl) carbonate
trichloromethyl chloroformate
(fluorenylmethoxy)carbonyl chloride
2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one
1,3-dihydro-imidazo[4,5-b]pyridin-2-one
2,5-dioxopyrrolidin-1-yl octanoate
benzyl caprylate
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