Intermediate of API

770-12-7

  • Product Name:Phenyl dichlorophosphate
  • Molecular Formula:C6H5Cl2O2P
  • Specifications:99%
  • Molecular Weight:210.984
Inquiry

Product Details;

CasNo: 770-12-7

Molecular Formula: C6H5Cl2O2P

Appearance: colorless transparent liquid

High Grade 99% Purity Phenyl dichlorophosphate 770-12-7 In Bulk Supply

  • Molecular Formula:C6H5Cl2O2P
  • Molecular Weight:210.984
  • Appearance/Colour:colorless transparent liquid 
  • Vapor Pressure:0.0541mmHg at 25°C 
  • Melting Point:-1 °C 
  • Refractive Index:n20/D 1.523(lit.)  
  • Boiling Point:242 °C at 760 mmHg 
  • Flash Point:99.1 °C 
  • PSA:36.11000 
  • Density:1.466 g/cm3 
  • LogP:3.65110 

Phenyl dichlorophosphate(Cas 770-12-7) Usage

Chemical Properties

clear colourless to very slightly brown liquid

Uses

In organic synthesis for preparation of lactams, phosphate diesters and for oxidation reactions.

General Description

A liquid. May severely irritate skin, eyes and mucous membranes.

Air & Water Reactions

About the same density as water and moderately soluble in water.

Reactivity Profile

An hologenated organophosphate. Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

InChI:InChI=1/C6H5Cl2O2P/c7-11(8,9)10-6-4-2-1-3-5-6/h1-5H

770-12-7 Relevant articles

Phenyl dichlorophosphate as an activating agent in the Pfitzner-Moffatt oxidation

HJ Liu, JM Nyangulu

Tetrahedron Letters Volume 29, Issue 26, 1988, Pages 3167-3170

Phenyl dichlorophosphate has been shown to be a highly efficient activating agent for dimethyl sulfoxide in the Pfitzner-Moffatt oxidation. Phenyl dichlorophosphate has been shown to be a highly efficient activating agent for dimethyl sulfoxide in the Pfitzner-Moffatt oxidation.

Organophosphorous phenyl phosphates: Synthesis, dye/protein interactions and antimicrobial evaluation

Ameta, Rakesh Kumar,Duan, Yongtao,Koshti, Rohit R.,Muddassir, Mohd.,Patel, Amee S.,Trivedi, Nidhi S.,Vyas, Akshay

, (2021/01/09)

A series of Phenyl Phosphates (PPs) has ...

Beckmann rearrangement of ketoximes induced by phenyl dichlorophosphate at ambient temperature

CW Kuo, MT Hsieh, S Gao, YM Shao, CF Yao, KS Shia

Molecules, 2012

Herein, we wish to report that a convenient new procedure, making use of phenyl dichlorophosphate (3) as a key activating agent, has been developed in our laboratories to facilitate the title rearrangement at room temperature.

770-12-7 Process route

phenol
108-95-2,27073-41-2

phenol

phosphoric acid triphenyl ester
115-86-6

phosphoric acid triphenyl ester

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

Conditions
Conditions Yield
With magnesium chloride; trichlorophosphate; In xylene; at 90 - 110 ℃; Kinetics; Product distribution; Rate constant;
 
With trichlorophosphate; at 102 - 240 ℃;
 
phosphorus trichloride
7719-12-2,52843-90-0

phosphorus trichloride

phenol
108-95-2,27073-41-2

phenol

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

Conditions
Conditions Yield
at 140 ℃;
 

770-12-7 Upstream products

  • 108-95-2
    108-95-2

    phenol

  • 3426-89-9
    3426-89-9

    phenyl phosphorodichloridite

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    sodium phenoxide

  • 19579-04-5
    19579-04-5

    tetrachlorophenoxyphosphorane

770-12-7 Downstream products

  • 22564-57-4
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    bis(2-chloroethyl) phenyl phosphate

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    bis-aziridin-1-yl-phosphinic acid phenyl ester

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    Phosphorsaeurephenylesterdipiperidid

  • 4881-17-8
    4881-17-8

    di-morpholin-4-yl-phosphinic acid phenyl ester

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