Intermediate of API

65185-58-2

  • Product Name：2-Bromophenethylamine
  • Molecular Formula：C8H10BrN
  • Specifications：99%
  • Molecular Weight：200.078
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Product Details;

CasNo： 65185-58-2

Molecular Formula： C8H10BrN

Appearance： clear colorless to slightly yellow liquid

Fast Delivery 2-Bromophenethylamine 65185-58-2 Liquid with Best Price

  • Molecular Formula:C8H10BrN
  • Molecular Weight:200.078
  • Appearance/Colour:clear colorless to slightly yellow liquid 
  • Vapor Pressure:0.0137mmHg at 25°C 
  • Refractive Index:n20/D 1.5770(lit.)  
  • Boiling Point:258.5 °C at 760 mmHg 
  • PKA:9.52±0.10(Predicted) 
  • Flash Point:110.1 °C 
  • PSA：26.02000 
  • Density:1.407 g/cm3 
  • LogP:2.65060 

2-Bromophenethylamine(Cas 65185-58-2) Usage

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

2-(2-Bromophenyl)ethylamine is used as a pharmaceutical intermediate. In some studies, a successful selective synthesis of indolines was performed via intramolecular C—N the bond-forming reaction of 2-bromophenethylamine derivatives .

General Description

May darken in storage

InChI:InChI=1/C8H10BrN/c9-8-4-2-1-3-7(8)5-6-10/h1-4H,5-6,10H2/p+1

65185-58-2 Relevant articles

Reaction of Diisobutylaluminum Borohydride, a Binary Hydride, with Selected Organic Compounds Containing Representative Functional Groups

Amberchan, Gabriella,Snelling, Rachel A.,Moya, Enrique,Landi, Madison,Lutz, Kyle,Gatihi, Roxanne,Singaram, Bakthan

supporting information, p. 6207 - 6227 (2021/05/06)

The binary hydride, diisobutylaluminum b...

Pd2dba3/P (i-BuNCH2CH2) 3N: a highly efficient catalyst for the one-pot synthesis of trans-4-N, N-diarylaminostilbenes and N, N-diarylaminostyrenes

MV Nandakumar, JG Verkade

Paragraph 0163-0168, (2019/10/15)

The reaction of 2-bromophenethylamine with 2-bromophenylboronic acid in the presence of 4 mol% of Pd(OAc) 2 and 8 mol% of 1 at 110 C for 24 h afforded 11 in 53% isolated yield ...

A One‐Pot, Three‐Component Approach to Functionalised Tetrahydroisoquinolines Using Domino Heck–aza‐Michael Reactions

DL Priebbenow, FM Pfeffer, SG Stewart

, European Journal of Organic Chemistry, Volume2011, Issue9 March 2011 Pages 1632-1635

Using this method tetrahydroisoquinolines 4–8 were formed by reaction of 2-bromophenethylamine (3) with commercial acrylates using either the Pd(OAc) 2 /PPh 3 or the Pd(OAc) 2 /…

Preparation of Indoles and Indolines via Pd/C-Mediated Cross-Couplings

Y Uozumi, YMA Yamada, H Baek

, Synfacts, 2014

The one-pot synthesis of N-arylated indoles was also performed from 2-bromophenethylamine via intramolecular cross-coupling and N-arylation with aryl bromides. …

65185-58-2 Process route

2-(2-bromophenyl)acetonitrile
19472-74-3

2-(2-bromophenyl)acetonitrile

2-(2-bromophenyl)ethanamine
65185-58-2

2-(2-bromophenyl)ethanamine

Conditions
Conditions Yield
2-(2-bromophenyl)acetonitrile; With borane tetrahydrofuran; In tetrahydrofuran; for 24h; Reflux;
With methanol; sulfuric acid; In tetrahydrofuran; water; at 20 ℃; for 1h;
With sodium hydroxide; In tetrahydrofuran; water;
94%
With potassium hydroxide;
93%
With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; for 18h;
90%
With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; 1.) 0 deg C, 10 min, 2.) room temp., 2 h;
87%
With sodium tetrahydroborate; In water; at 100 ℃; for 12h; pH=5.5;
87%
With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether;
85%
2-(2-bromophenyl)acetonitrile; With borane-THF; In tetrahydrofuran; at 0 ℃; for 24.5h; Reflux;
for 4h; Reflux;
85.2%
2-(2-bromophenyl)acetonitrile; With borane-THF; In tetrahydrofuran; at 80 ℃; for 24h; Cooling with ice;
With hydrogenchloride; In tetrahydrofuran; methanol; water; at 80 ℃; for 4h;
85.2%
With lithium aluminium tetrahydride;
82%
With lithium borohydride; diisopropopylaminoborane; In tetrahydrofuran; for 18h; Reflux;
80%
With diisobutylaluminum borohydride; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;
74%
With borane-THF; In tetrahydrofuran; at 0 - 20 ℃;
50%
With lithium aluminium tetrahydride;
 
With sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;
600 mg (55%)
With sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;
600 mg (55%)
With aluminum (III) chloride; lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 3h; Inert atmosphere;
 
With sodium tetrahydroborate; nickel dichloride;
 
With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In methanol; at 0 - 20 ℃; for 1.5h;
 
2-(2-bromophenyl)acetamide
65999-53-3

2-(2-bromophenyl)acetamide

2-(2-bromophenyl)ethanamine
65185-58-2

2-(2-bromophenyl)ethanamine

Conditions
Conditions Yield
With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃;
70.4%

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