Intermediate of API

946511-97-3

  • Product Name：(S)-2-Ethylbutyl 2-aminopropanoate hydrochloride
  • Molecular Formula：
  • Specifications：99%
  • Molecular Weight：209.716
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Product Details;

CasNo： 946511-97-3

Pharmaceutical Intermediates 99% Purity (S)-2-Ethylbutyl 2-aminopropanoate hydrochloride 946511-97-3 Best Price

  • Molecular Formula:C9H19NO2*ClH
  • Molecular Weight:209.716
  • Melting Point:77 - 79°C 

2-ethylbutyl (S)-2-aminopropanoate hydrochloride(Cas 946511-97-3) Usage

Uses

L-Alanine 2-Ethylbutyl Ester Hydrochloride is used in the synthesis of phosphoramidate prodrug of a pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-5734) for the treatment of ebola and emerging viruses.

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946511-97-3 Process route

L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

2-ethyl-1-butanol
97-95-0

2-ethyl-1-butanol

2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
With chloro-trimethyl-silane; at 20 ℃; for 18h;
85%
With chloro-trimethyl-silane; at 20 ℃; for 18h; Inert atmosphere;
85%
L-alanin
56-41-7,25191-17-7,18875-37-1

L-alanin

2-ethyl-1-butanol
97-95-0

2-ethyl-1-butanol

2-ethylbutyl (S)-2-aminopropanoate hydrochloride
946511-97-3

2-ethylbutyl (S)-2-aminopropanoate hydrochloride

Conditions
Conditions Yield
L-alanin; 2-ethyl-1-butanol; at 0 ℃; for 0.0833333h;
With thionyl chloride; at 60 ℃; for 10h;
80%
2-ethyl-1-butanol; With thionyl chloride; at 0 ℃; for 1h;
L-alanin; at 0 - 90 ℃; for 16h;
74%

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    2-ethyl-1-butanol

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    L-N-Boc-Ala

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