- Language:English
- English
CasNo： 77383-17-6
The present invention relates to a targe...
The present disclosure relates to novel ...
Detection of metabolic activity in livin...
The present disclosure provides compound...
8-bromooctanoic acid
tert-butyl alcohol
8-bromo-octanoic acid tert-butyl ester
| Conditions | Yield |
|---|---|
|
8-bromooctanoic acid;
With
trifluoroacetic anhydride;
In
dichloromethane;
at 0 ℃;
for 2.5h;
Inert atmosphere;
tert-butyl alcohol;
In
dichloromethane;
at 0 - 20 ℃;
|
99% |
|
8-bromooctanoic acid;
With
trifluoroacetic anhydride;
In
dichloromethane;
at 0 ℃;
for 2.5h;
Inert atmosphere;
tert-butyl alcohol;
In
dichloromethane;
at 20 ℃;
for 3.5h;
Inert atmosphere;
|
96% |
|
8-bromooctanoic acid;
With
thionyl chloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 1.5h;
Inert atmosphere;
tert-butyl alcohol;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
|
68% |
|
With
sulfuric acid; magnesium sulfate;
In
dichloromethane;
at 20 ℃;
for 18h;
|
65% |
|
8-bromooctanoic acid;
With
trifluoroacetic anhydride;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
tert-butyl alcohol;
In
dichloromethane;
at 20 ℃;
for 12h;
|
65% |
|
8-bromooctanoic acid;
With
trifluoroacetic anhydride;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
tert-butyl alcohol;
In
dichloromethane;
at 20 ℃;
for 12h;
|
65% |
|
8-bromooctanoic acid;
With
trifluoroacetic anhydride;
In
dichloromethane;
at 0 ℃;
for 2.5h;
tert-butyl alcohol;
In
dichloromethane;
at 0 - 20 ℃;
for 3.5h;
|
60% |
|
8-bromooctanoic acid;
With
trifluoroacetic anhydride;
In
dichloromethane;
at 0 ℃;
for 2.5h;
tert-butyl alcohol;
In
dichloromethane;
at 0 - 20 ℃;
for 3.5h;
|
60% |
|
With
di-tert-butyl dicarbonate; magnesium chloride;
at 40 ℃;
for 48h;
|
55% |
|
8-bromooctanoic acid;
With
trifluoroacetic anhydride;
In
tetrahydrofuran;
at -40 ℃;
for 0.5h;
tert-butyl alcohol;
In
tetrahydrofuran;
at -40 - 20 ℃;
for 16h;
|
44% |
|
With
ethyl bromide; oxalyl dichloride; sodium bromide;
Yield given. Multistep reaction;
1.) DMF, MeCN, -18 deg C, 40 min, 2.) MeCN, -18 deg C, 45 min, 3.) pyridine, -18 deg C, 0.5 h; -18 deg C to room temperature, 20 h;
|
|
|
With
dmap; dicyclohexyl-carbodiimide;
In
dichloromethane;
at 20 ℃;
for 48h;
|
|
|
8-bromooctanoic acid;
With
trifluoroacetic anhydride;
In
dichloromethane;
at 0 ℃;
for 2.5h;
tert-butyl alcohol;
In
dichloromethane;
at 0 - 20 ℃;
for 3.5h;
|
|
|
8-bromooctanoic acid;
With
trifluoroacetic anhydride;
In
dichloromethane;
at 0 ℃;
for 2.5h;
tert-butyl alcohol;
In
dichloromethane;
for 1h;
|
8-bromooctanoic acid
di-tert-butyl dicarbonate
8-bromo-octanoic acid tert-butyl ester
| Conditions | Yield |
|---|---|
|
With
dmap;
In
dichloromethane; tert-butyl alcohol;
at 20 ℃;
for 16h;
|
|
|
With
dmap;
In
dichloromethane; tert-butyl alcohol;
at 20 ℃;
for 16h;
|
8-bromooctanoic acid
isobutene
tert-butyl alcohol
tert-Butyl 2,2,2-trichloroacetimidate
ω-(imidazol-1-yl)octanoic acid
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