Chemical intermediate

7236-57-9

  • Product Name：4-Thiothymidin
  • Molecular Formula：C10H14N2O4S
  • Specifications：99%
  • Molecular Weight：258.298
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Product Details;

CasNo： 7236-57-9

Molecular Formula： C10H14N2O4S

Cosmetics Grade 4-Thiothymidin 7236-57-9 For Sale with Good Price

  • Molecular Formula:C10H14N2O4S
  • Molecular Weight:258.298
  • Refractive Index:1.672 
  • PSA：119.57000 
  • Density:1.52g/cm3 
  • LogP:-0.14500 

Thymidine, 4-thio-(Cas 7236-57-9) Usage

General Description

4-thio-thymidine is a chemical analog of the nucleoside, thymidine, which is commonly found in DNA. Thymidine, 4-thio- has a sulfur atom replacing an oxygen atom in the thymidine molecule, which gives it unique photo-reactive properties. It is often used in research as a molecular probe to study the dynamics of DNA and RNA due to its ability to form covalent bonds upon exposure to UV light. It is efficiently incorporated into DNA and its absorbance and fluorescence properties enable it to be tracked and visualized in biological systems.

InChI:InChI=1/C10H14N2O4S/c1-5-3-12(10(15)11-9(5)17)8-2-6(14)7(4-13)16-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,17)/t6-,7+,8+/m0/s1

7236-57-9 Relevant articles

4 - Thiodeoxythymidine derivative and anti-hepatitis B virus pharmaceutical application thereof

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, (2021/10/05)

4 - Thio-deoxythymidine derivatives and ...

Exploring the binding of 4-thiothymidine with human serum albumin by spectroscopy, atomic force microscopy, and molecular modeling methods

Zhang, Juling,Gu, Huaimin,Zhang, Xiaohui

, p. 102 - 111 (2014/01/17)

The interaction of 4-thiothymidine (S4Td...

Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides

Zhang, Xiaohui,Wang, Jian,Xu, Yao-Zhong

, p. 523 - 529 (2013/09/02)

Unambiguous characterization of 5-substi...

NMR and UV studies of 4-thio-2′-deoxyuridine and its derivatives

Zhang, Xiaohui,Xu, Yao-Zhong

, p. 5655 - 5664 (2011/09/20)

5-Substituted-4-thio-2'-deoxyuridine nuc...

7236-57-9 Process route

3',5'-di-O-acetyl-4-thiothymidine
20188-74-3

3',5'-di-O-acetyl-4-thiothymidine

4-thiothymidine
7236-57-9

4-thiothymidine

Conditions
Conditions Yield
With ammonia; In methanol;
With ammonia; In methanol; at 20 ℃; for 4.5h;
With methanol; at 20 ℃; Alkaline conditions;
22.6 g
thymidine
50-89-5,28854-96-8,3545-96-8,50-88-4

thymidine

4-thiothymidine
7236-57-9

4-thiothymidine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: pyridine
2: aqueous pyridine; P2S5
3: methanol. sodium methylate
With pyridine; tetraphosphorus decasulfide; sodium methylate;
Multi-step reaction with 4 steps
1.1: triethylamine / tetrahydrofuran / 2.5 h / Cooling with ice
2.1: triethylamine; trichlorophosphate / acetonitrile / 0 °C
2.2: 16 h / 20 °C
3.1: acetonitrile / Cooling with ice
4.1: hydrogenchloride; water / tetrahydrofuran / 20 h / 20 °C / pH 3
With hydrogenchloride; water; triethylamine; trichlorophosphate; In tetrahydrofuran; acetonitrile;
Multi-step reaction with 3 steps
1: pyridine
2: tetraphosphorus decasulfide / 1,4-dioxane
3: ammonia / methanol
With pyridine; tetraphosphorus decasulfide; ammonia; In 1,4-dioxane; methanol;
Multi-step reaction with 3 steps
1: pyridine / 5 h / 0 °C
2: tetraphosphorus decasulfide / 1,4-dioxane / 1.5 h / 106 °C
3: ammonia / methanol / 4.5 h / 20 °C
With pyridine; tetraphosphorus decasulfide; ammonia; In 1,4-dioxane; methanol;
Multi-step reaction with 3 steps
1: pyridine / 20 °C
2: Lawessons reagent / toluene / 4 h / 97 °C
3: methanol / 20 °C / Alkaline conditions
With Lawessons reagent; pyridine; methanol; In toluene;

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