Chemical intermediate

156545-07-2

  • Product Name：3,5-Difluorophenylboronic acid
  • Molecular Formula：C6H5BF2O2
  • Specifications：99%
  • Molecular Weight：157.912
Inquiry

Product Details;

CasNo： 156545-07-2

Molecular Formula： C6H5BF2O2

Appearance： White to beige-yellowish powder

Factory Sells Best Quality 3,5-Difluorophenylboronic acid 156545-07-2 with GMP standards

  • Molecular Formula:C6H5BF2O2
  • Molecular Weight:157.912
  • Appearance/Colour:White to beige-yellowish powder 
  • Vapor Pressure:1.04E-07mmHg at 25°C 
  • Melting Point:210-217 °C 
  • Refractive Index:1.562 
  • Boiling Point:266.9 °C at 760 mmHg 
  • PKA:6.46±0.10(Predicted) 
  • Flash Point:115.2 °C 
  • PSA：40.46000 
  • Density:1.35 g/cm3 
  • LogP:-0.35540 

3,5-DifluoroPhenylboronic acid(Cas 156545-07-2) Usage

InChI:InChI=1/C13H11BF2O3/c15-12-10(14(17)18)6-7-11(13(12)16)19-8-9-4-2-1-3-5-9/h1-7,17-18H,8H2

156545-07-2 Relevant articles

Meso-substituted boron-dipyrromethene compounds: synthesis, tunable solid-state emission, and application in blue-driven LEDs

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Scope of the palladium-catalyzed aryl borylation utilizing bis-boronic acid

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The Suzuki-Miyaura reaction has become o...

156545-07-2 Process route

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

boric acid
11113-50-1,14635-83-7

boric acid

3,5-difluorophenylboronic acid
156545-07-2

3,5-difluorophenylboronic acid

Conditions
Conditions Yield
3,5-difluorobromobenzene; With n-butyllithium; In tetrahydrofuran; at -60 ℃; for 2h; Inert atmosphere;
boric acid; In tetrahydrofuran; for 1h; Temperature; Inert atmosphere;
85.8%
Trimethyl borate
121-43-7,63156-11-6

Trimethyl borate

3,5-difluorobromobenzene
461-96-1

3,5-difluorobromobenzene

3,5-difluorophenylboronic acid
156545-07-2

3,5-difluorophenylboronic acid

Conditions
Conditions Yield
With hydrogenchloride; magnesium; In tetrahydrofuran;
With hydrogenchloride; tert.-butyl lithium; In diethyl ether; cyclohexane;
3,5-difluorobromobenzene; With magnesium; In tetrahydrofuran; at 45 - 55 ℃; Inert atmosphere;
Trimethyl borate; In tetrahydrofuran; at -70 - 0 ℃; Inert atmosphere;
With hydrogenchloride; water; In tetrahydrofuran; ethyl acetate; at 0 ℃;
3,5-difluorobromobenzene; With magnesium; In tetrahydrofuran; at 40 ℃; for 1h; Inert atmosphere; Cooling with ice;
Trimethyl borate; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere; Cooling with ice;
With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 0.5h; Inert atmosphere;
71.65 g
With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

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