intermediate of API

60133-18-8

  • Product Name：1α ,25-Dihydroxy vitamin D2
  • Molecular Formula：C28H44O3
  • Specifications：99%
  • Molecular Weight：428.656
Inquiry

Product Details;

CasNo： 60133-18-8

Molecular Formula： C28H44O3

Factory Sells Best Quality 1α ,25-Dihydroxy vitamin D2 60133-18-8 with steady supply

  • Molecular Formula:C28H44O3
  • Molecular Weight:428.656
  • Vapor Pressure:0mmHg at 25°C 
  • Refractive Index:1.554 
  • Boiling Point:577.655 °C at 760 mmHg 
  • PKA:14.43±0.40(Predicted) 
  • Flash Point:242.511 °C 
  • PSA：60.69000 
  • Density:1.066 g/cm3 
  • LogP:5.72670 

1(ALPHA) 25-DIHYDROXYVITAMIN D2*(Cas 60133-18-8) Usage

Biochem/physiol Actions

Ergocalciferol (vitamin D2) is activated in vivo by hydroxylation to 25-hydroxyergocalciferol and 1α,25-dihydroxycalciferol. Activated Vitamin D2 molecules may be used in a wide range of studies to assess their effects on functions such as immune function and calcium homeostasis.

Definition

ChEBI: A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25.

General Description

1α,25-Dihydroxyvitamin D2?is an active form of vitamin D2. It is also known as ercalcitriol or 1α,25-dihydroxyergocalciferol. It was first isolated from mitochondria of chick kidney.

InChI:InChI=1/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25+,26+,28-/m1/s1

60133-18-8 Relevant articles

A Short, Efficient Copper-Mediated Synthesis of 1α,25-Dihydroxyvitamin D2 (1α,25-Dihydroxyergocalciferol) and C-24 Analogs

Torneiro, Mercedes,Fall, Yagamare,Castedo, Luis,Mouri?o, Antonio

, p. 6344 - 6352 (2007/10/03)

Two synthetic routes to the nonnatural h...

Studies on the opening of dioxanone and acetal templates and application to the synthesis of 1α,25-dihydroxyvitamin D2

Granja,Castedo,Mourino

, p. 124 - 131 (2007/10/02)

-

Process for the preparation of 1α,25-dihydroxyvitamin D2 and the 24-epimer thereof

-

, (2008/06/13)

(22E)-5,7,22-Ergostatriene-1α,3β,25-trio...

A new and convenient synthesis of 1α,25-dihydroxyvitamin D2 and its 24R-epimer

Tsuji,Yokoyama,Tachibana

, p. 3132 - 3137 (2007/10/02)

-

60133-18-8 Process route

1α-[(tert-butyldimethylsilyl)oxy]-25-[(methoxymethyl)oxy]previtamin D<sub>2</sub> tert-butyldimethylsilyl ether
145354-39-8

1α-[(tert-butyldimethylsilyl)oxy]-25-[(methoxymethyl)oxy]previtamin D2 tert-butyldimethylsilyl ether

ercalcitriol
60133-18-8

ercalcitriol

Conditions
Conditions Yield
With ion-exchange resin AG 50W-X4; In methanol; for 48h; Ambient temperature; in the dark;
82%
With AG50 WX4 resin; tetrabutyl ammonium fluoride; Yield given. Multistep reaction; 1) THF, , 12 h, rt; 2) MeOH, rt, 5 h;
aqueous potassium nitrate

aqueous potassium nitrate

(22E)-5,7,22-ergostatriene-1α,3β,25-triol
125732-35-6

(22E)-5,7,22-ergostatriene-1α,3β,25-triol

ercalcitriol
60133-18-8

ercalcitriol

Conditions
Conditions Yield
In tetrahydrofuran; ethanol; nitrogen;

60133-18-8 Upstream products

  • 95716-69-1
    95716-69-1

    1R-<1α(1R*,2E,4S*),3aβ,7aα>-octahydro-1-<5-<(trimethylsilyl)oxy>-1,4,5-trimethyl-2-hexenyl>-7a-methyl-4H-inden-4-one

  • 81522-68-1
    81522-68-1

    [(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

  • 145354-39-8
    145354-39-8

    1α-[(tert-butyldimethylsilyl)oxy]-25-[(methoxymethyl)oxy]previtamin D2 tert-butyldimethylsilyl ether

  • 125732-36-7
    125732-36-7

    previtamin D

Relevant Products