Chemical intermediate

139301-27-2

  • Product Name：4-Trifluoromethoxyphenylboronic acid
  • Molecular Formula：C7H6BF3O3
  • Specifications：99%
  • Molecular Weight：205.929
Inquiry

Product Details;

CasNo： 139301-27-2

Molecular Formula： C7H6BF3O3

Appearance： white to beige crystalline powder

Top Quality Chinese Manufacturer supply 139301-27-2 4-Trifluoromethoxyphenylboronic acid

  • Molecular Formula:C7H6BF3O3
  • Molecular Weight:205.929
  • Appearance/Colour:white to beige crystalline powder 
  • Vapor Pressure:0.00786mmHg at 25°C 
  • Melting Point:123-127 °C(lit.) 
  • Refractive Index:1.461 
  • Boiling Point:256.6 °C at 760 mmHg 
  • PKA:8.29±0.10(Predicted) 
  • Flash Point:109 °C 
  • PSA：49.69000 
  • Density:1.41 g/cm3 
  • LogP:0.26500 

4-Trifluoromethoxyphenylboronic acid(Cas 139301-27-2) Usage

Application

4-Trifluoromethoxyphenylboronic acid can reactant involved in the synthesis of biologically active molecules including:Lactate dehydrogenase inhibitors for use against cancer cell proliferationNitro-phenoxybenzoic acid derivatives for PAI-1 inhibitionPA-824 analogs for use as antituberculosis drugsModulators of survival motor neuron proteinReactant involved in addition reactions and cross-coupling reactions including Suzuki-Miyaura cross-coupling

InChI:InChI=1/C7H6BF3O3/c9-7(10,11)14-6-3-1-5(2-4-6)8(12)13/h1-4,12-13H

139301-27-2 Relevant articles

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In this study, we developed a simple tra...

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139301-27-2 Process route

4-chloro-2-(4-trifluoromethoxy-phenyl)-quinoline

4-chloro-2-(4-trifluoromethoxy-phenyl)-quinoline

3-(trifluoromethyl)pyrazole
20154-03-4

3-(trifluoromethyl)pyrazole

4-trifluoromethoxyphenylboronic acid
139301-27-2

4-trifluoromethoxyphenylboronic acid

Conditions
Conditions Yield
With sodium hydride; In N,N-dimethyl-formamide; at 80 - 100 ℃; for 14h;
52%
Triisopropyl borate
5419-55-6

Triisopropyl borate

1-bromo-4-(trifluoromethoxy)benzene
407-14-7

1-bromo-4-(trifluoromethoxy)benzene

4-trifluoromethoxyphenylboronic acid
139301-27-2

4-trifluoromethoxyphenylboronic acid

Conditions
Conditions Yield
With hydrogenchloride; n-butyllithium; sodium chloride; In tetrahydrofuran; n-heptane;
1.306 kg (90.4%)
With hydrogenchloride; magnesium; In tetrahydrofuran;

139301-27-2 Upstream products

  • 407-14-7
    407-14-7

    1-bromo-4-(trifluoromethoxy)benzene

  • 20154-03-4
    20154-03-4

    3-(trifluoromethyl)pyrazole

  • 5419-55-6
    5419-55-6

    Triisopropyl borate

  • 13675-18-8
    13675-18-8

    tetrahydroxydiboron

139301-27-2 Downstream products

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    173025-79-1

    4-(4'-trifluoromethoxy phenyl)-phenol

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    5-(4-trifluoromethoxyphenyl) furan-2-formaldehyde

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