intermediate of API

57333-96-7

  • Product Name：Tacalcitol
  • Molecular Formula：C27H44O3
  • Specifications：99%
  • Molecular Weight：416.645
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Product Details;

CasNo： 57333-96-7

Molecular Formula： C27H44O3

Factory Sells Best Quality Tacalcitol 57333-96-7 with ISO standards

  • Molecular Formula:C27H44O3
  • Molecular Weight:416.645
  • Vapor Pressure:4.05E-15mmHg at 25°C 
  • Refractive Index:1.545 
  • Boiling Point:565 °C at 760 mmHg 
  • PKA:14.43±0.40(Predicted) 
  • Flash Point:238.4 °C 
  • PSA：60.69000 
  • Density:1.06 g/cm3 
  • LogP:5.56060 

Tacalcitol(Cas 57333-96-7) Usage

Safety Profile

A poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors,

Brand name

Bonalfa

InChI:InChI=1/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1

57333-96-7 Relevant articles

Process Development of Tacalcitol

Lee, Seung Jong,Moon, Hyung Wook,Lee, Kee-Young,Oh, Chang Young,Kim, U Bin,Shin, Hyunik

, p. 982 - 987 (2021/03/15)

A highly convergent, gram-scale synthesi...

Process for Preparing Tacalcitol and Intermediate Therefor

-

Paragraph 0051; 0269; 0270, (2018/12/12)

The present invention relates to a proce...

Enantiomeric impurity PY2 of tacalcitol and preparation method and application thereof

-

Paragraph 0034, (2018/05/30)

The invention discloses an enantiomeric ...

Modified Julia olefination and α aminoxylation reactions mediated convergent synthesis of 1α, 24 (R)-dihydroxyvitamin D3 (tacalcitol)

Martínez, Andrea,Santalla, Hugo,Garrido, Fátima,Gómez, Generosa,Fall, Yagamare

supporting information, p. 3568 - 3570 (2017/10/06)

A convergent synthesis of tacalcitol has...

57333-96-7 Process route

((1R,3S,Z)-5-((E)-2-((1R,7aR)-7a-methyl-1((2R,5R)-6-methyl-5-(triethylsilyloxy)heptan-2-yl)dihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy)bis(tert-butyldimethylsilane)

((1R,3S,Z)-5-((E)-2-((1R,7aR)-7a-methyl-1((2R,5R)-6-methyl-5-(triethylsilyloxy)heptan-2-yl)dihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy)bis(tert-butyldimethylsilane)

tacalcitol
57333-96-7

tacalcitol

Conditions
Conditions Yield
With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Darkness;
98%
With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 40h; Darkness;
98%
(1R,3S)-5-[2-[(1R,3aS,7aR)-1-((1R,4R)-4-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexane-1,3-diol

(1R,3S)-5-[2-[(1R,3aS,7aR)-1-((1R,4R)-4-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexane-1,3-diol

tacalcitol
57333-96-7

tacalcitol

Conditions
Conditions Yield
With hydrogen fluoride; In water; acetonitrile; at 20 ℃; for 24h;
76%
With methanol; AG 50W-X4 resin; at 20 ℃;
33 mg

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