intermediate of API

83805-11-2

  • Product Name：Falecalcitriol
  • Molecular Formula：C27H38F6O3
  • Specifications：99%
  • Molecular Weight：524.587
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Product Details;

CasNo： 83805-11-2

Molecular Formula： C27H38F6O3

Manufacturer supply high quality Falecalcitriol 83805-11-2 with GMP standards

  • Molecular Formula:C27H38F6O3
  • Molecular Weight:524.587
  • Vapor Pressure:1.03E-15mmHg at 25°C 
  • Refractive Index:1.504 
  • Boiling Point:576.9 °C at 760 mmHg 
  • Flash Point:302.7 °C 
  • PSA：60.69000 
  • Density:1.24 g/cm3 
  • LogP:6.78950 

FALECALCITRIOL(Cas 83805-11-2) Usage

Hazard

A poison by ingestion.

Brand name

Hornel, Fulstan

InChI:InChI=1/C27H38F6O3/c1-16(6-4-13-25(36,26(28,29)30)27(31,32)33)21-10-11-22-18(7-5-12-24(21,22)3)8-9-19-14-20(34)15-23(35)17(19)2/h8-9,16,20-23,34-36H,2,4-7,10-15H2,1,3H3/b18-8+,19-9-/t16-,20-,21-,22+,23+,24-/m1/s1

83805-11-2 Relevant articles

Synthesis and biological evaluations of A-ring isomers of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3

Ikeda, Masahiko,Takahashi, Kazuhiko,Dan, Akihito,Koyama, Kohji,Kubota, Katsumi,Tanaka, Tomoyuki,Hayashi, Masaji

, p. 2157 - 2166 (2007/10/03)

The activated vitamin D3 derivative 26,2...

Kinetics of thermal [1,7A]-sigmatropic shift of hexafluoro vitamin D3 and vitamin D3 derivatives. Evaluation of conformations of the A ring affected by 1-OH and 3-OH groups

Igarashi, Jun-Etsu,Ikeda, Masahiko,Sunagawa, Makoto

, p. 1431 - 1436 (2007/10/03)

The quantitative evaluation of the [1,7a...

Immunosuppressive agents

-

, (2008/06/13)

The invention relates to pharmaceutical ...

Studies on organic fluorine compounds. XXXIX. Studies on steroids. LXXIX. Synthesis of 1α,25-dihydroxy-26,26,26,27,27,27-hexafluorovitamin D3

Kobayashi,Taguchi,Mitsuhashi,et al.

, p. 4297 - 4303 (2007/10/02)

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83805-11-2 Process route

(5Z,7E)-(1S,3R)-1,3-bis[(t-butyldimethylsilyl)oxy]-26,26,26,27,27,27-hexafluoro-25-methoxymethoxy-9,10-seco-5,7,10<sup>(19)</sup>-cholestatriene
163392-53-8

(5Z,7E)-(1S,3R)-1,3-bis[(t-butyldimethylsilyl)oxy]-26,26,26,27,27,27-hexafluoro-25-methoxymethoxy-9,10-seco-5,7,10(19)-cholestatriene

Falecalcitriol
83805-11-2

Falecalcitriol

Conditions
Conditions Yield
With methanesulfonic acid; In methanol; at 20 ℃; for 2h;
56%
26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholecalciferol triacetate

26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholecalciferol triacetate

Falecalcitriol
83805-11-2

Falecalcitriol

Conditions
Conditions Yield
With potassium hydroxide; In tetrahydrofuran; methanol; for 14h; Ambient temperature; in the dark;
90%

83805-11-2 Upstream products

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    163392-53-8

    (5Z,7E)-(1S,3R)-1,3-bis[(t-butyldimethylsilyl)oxy]-26,26,26,27,27,27-hexafluoro-25-methoxymethoxy-9,10-seco-5,7,10(19)-cholestatriene

  • 143884-26-8
    143884-26-8

    (5Z,7E,20R)-1α,3β-bis<(tert-butyldimethylsilyl)oxy>-20-formylmethyl-9,10-seco-5,7,10(19)-pregnatriene

  • 167892-99-1
    167892-99-1

    1α,3β-bis[(t-butyldimethylsilyl)oxy]-20(S)-(n-propyl-23-oxo)-9,10-secopregna-5(Z),7(E),10(19)-triene

  • 167893-00-7
    167893-00-7

    1α,3β-bis[(t-butyldimethylsilyl)oxy]-26,26,26,27,27,27-hexafluoro-23-oxo-9,10-secocholesta-5(Z),7(E),10(19)-trien-25-ol

83805-11-2 Downstream products

  • 210907-37-2
    210907-37-2

    (6Z)-(3R)-26,26,26,27,27,27-hexafluoro-9,10-seco-5(10),6,8-cholestatriene-3,25-diol-1-one

  • 210907-40-7
    210907-40-7

    (6Z)-(1R,3R)-26,26,26,27,27,27-hexafluoro-9,10-seco-5(10),6,8-cholestatriene-1β,3β,25-triol

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