intermediate of API

54-25-1

  • Product Name：6-Azauridine
  • Molecular Formula：C8H11 N3 O6
  • Specifications：99%
  • Molecular Weight：245.192
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Product Details;

CasNo： 54-25-1

Molecular Formula： C8H11 N3 O6

Buy Quality 6-Azauridine 54-25-1 In Stock with Immediately Delivery

  • Molecular Formula:C8H11 N3 O6
  • Molecular Weight:245.192
  • Melting Point:157-159 °C(lit.) 
  • Refractive Index:1.7950 (estimate) 
  • Boiling Point:°Cat760mmHg 
  • PKA:6.70(at 25℃) 
  • Flash Point:°C 
  • PSA：137.67000 
  • Density:2.08 g/cm3 
  • LogP:-3.45690 

6-AZAURIDINE(Cas 54-25-1) Usage

Biochem/physiol Actions

6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites.

General Description

6-Azauridine is a pyrimidine nucleoside analog.

InChI:InChI=1/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)

54-25-1 Relevant articles

New non-aromatic triazinic nucleosides : Synthesis and antiretroviral evaluation of β-ribosylamine nucleoside analogs

Depelley, Jean,Granet, Robert,Kaouadji, Mourad,Krausz, Pierre,Piekarski, Salomon,Delebassee, Sylvie,Bosgiraud, Claudine

, p. 995 - 1008 (2007/10/03)

Various 5-alkyl-6-aza-5,6-dihydrouridine...

Hydrolysis of the prodrug, 2',3',5'-triacetyl-6-azauridine

Riley,Mummert,Zhou,Schowen,Vander Velde,Morton,Slavik

, p. 1361 - 1370 (2007/10/03)

Purpose. The purposes were to study the ...

2',3'-O-CARBONYL DERIVATIVES OF 6-AZAURIDINE IN THE SYNTHESIS OF ITS 5'-SUBSTITUTED AND 5'-DEOXY DERIVATIVES

Drasar, Pavel,Beranek, Jiri

, p. 2070 - 2082 (2007/10/02)

Preparation of 2',3'-O-carbonyl derivati...

54-25-1 Process route

2',3',5'-tri-O-acetyl-6-azauridine
2169-64-4

2',3',5'-tri-O-acetyl-6-azauridine

6-Azauridine
54-25-1

6-Azauridine

Conditions
Conditions Yield
With sodium methylate; In methanol; at 0 ℃; for 0.25h;
95%
6-azauridine 2',3'-O-carbonate
59967-97-4

6-azauridine 2',3'-O-carbonate

6-Azauridine
54-25-1

6-Azauridine

Conditions
Conditions Yield
In pyridine; water; at 100 ℃; for 0.75h;
89%

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