Intermediate of API

4803-74-1

  • Product Name：5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one
  • Molecular Formula：C17H15NO3
  • Specifications：99%
  • Molecular Weight：281.311
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Product Details;

CasNo： 4803-74-1

Molecular Formula： C17H15NO3

Hot Sale High Quality 5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one 4803-74-1 Competitive Price

  • Molecular Formula:C17H15NO3
  • Molecular Weight:281.311
  • Vapor Pressure:0mmHg at 25°C 
  • Melting Point:210-211 °C 
  • Refractive Index:1.639 
  • Boiling Point:499.9 °C at 760 mmHg 
  • PKA:5.10±0.10(Predicted) 
  • Flash Point:256.1 °C 
  • PSA：48.42000 
  • Density:1.256 g/cm3 
  • LogP:2.92120 

5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one(Cas 4803-74-1) Usage

Chemical Properties

Yellow Solid

Uses

An impurity of Donepezil.

InChI:InChI=1/C17H15NO3/c1-20-15-9-12-8-13(7-11-3-5-18-6-4-11)17(19)14(12)10-16(15)21-2/h3-7,9-10H,8H2,1-2H3/b13-7+

4803-74-1 Relevant articles

Synthesis, characterization and investigation of AChE and BuChE inhibitory activity of 1-alkyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium halide derivatives

Farrokhi, Hanieh,Mozaffarnia, Sakineh,Rahimpour, Keshvar,Rashidi, Mohammad Reza,Teimuri-Mofrad, Reza

, p. 593 - 600 (2020)

Abstract: The design, synthesis and char...

Synthesis method of donepezil hydrochloride

-

Paragraph 0037-0042; 0055-0062, (2019/05/15)

The invention belongs to the technical f...

Synthesis and anticonvulsant activity of 3a,4-dihydro-3Hindeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues

Ahsan, Mohamed Jawed,Khalilullah, Habibullah,Stables, James P.,Govindasamy, Jeyabalan

, p. 644 - 650 (2015/02/19)

A series of fourteen 3a,4-dihydro-3H-ind...

Synthesis and anticonvulsant activity of 3a,4-dihydro-3H-indeno[1,2-c] pyrazole-2-carboxamide/carbothioamide analogues

Ahsan, Mohamed Jawed,Khalilullah, Habibullah,Stables, James P.,Govindasamy, Jeyabalan

, p. 644 - 650 (2013/05/21)

A series of fourteen 3a,4-dihydro-3H-ind...

4803-74-1 Process route

pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

5,6-dimethoxy-1-indanone
2107-69-9

5,6-dimethoxy-1-indanone

5,6-dimethoxy-2-[(pyridin-4-yl)methylene]-1-indanone
4803-74-1

5,6-dimethoxy-2-[(pyridin-4-yl)methylene]-1-indanone

Conditions
Conditions Yield
With potassium hydroxide; In water; at 25 - 30 ℃; for 3h; Product distribution / selectivity;
98%
pyridine-4-carbaldehyde; 5,6-dimethoxy-1-indanone; With toluene-4-sulfonic acid; In toluene; for 6h; Heating / reflux;
With sodium carbonate; In water; for 0.5 - 1h;
95.8%
With potassium iodide; calcium chloride; In acetone; at 40 - 50 ℃; for 4h; Reagent/catalyst; Time;
92.2%
With sodium hydroxide; In ethanol; water; at 20 ℃; Inert atmosphere;
67%
With toluene-4-sulfonic acid; In toluene; for 6h; Heating / reflux;
With sodium hydroxide; In methanol; at 20 ℃; for 4h;
With sodium hydroxide; In methanol; at 20 ℃;
With sodium hydroxide; In methanol; at 20 ℃; for 4h;
pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

2-bromo-5,6-dimethoxy-1-indanone
2747-08-2

2-bromo-5,6-dimethoxy-1-indanone

5,6-dimethoxy-2-[(pyridin-4-yl)methylene]-1-indanone
4803-74-1

5,6-dimethoxy-2-[(pyridin-4-yl)methylene]-1-indanone

Conditions
Conditions Yield
With potassium tert-butylate; In dimethyl sulfoxide; at 15 - 20 ℃; Inert atmosphere;

4803-74-1 Upstream products

  • 872-85-5
    872-85-5

    pyridine-4-carbaldehyde

  • 2107-69-9
    2107-69-9

    5,6-dimethoxy-1-indanone

  • 2747-08-2
    2747-08-2

    2-bromo-5,6-dimethoxy-1-indanone

4803-74-1 Downstream products

  • 1034439-43-4
    1034439-43-4

    5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride

  • 1346911-31-6
    1346911-31-6

    3-(pyridin-4-yl)-N-(4-nitrophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide

  • 1346911-17-8
    1346911-17-8

    3-(4-chlorophenyl)-N-(4-fluorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide

  • 178551-26-3
    178551-26-3

    1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide

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