Chemical intermediate

138526-69-9

  • Product Name：1-Bromo-3,4,5-trifluorobenzene
  • Molecular Formula：C6H2BrF3
  • Specifications：99%
  • Molecular Weight：210.981
Inquiry

Product Details;

CasNo： 138526-69-9

Molecular Formula： C6H2BrF3

Appearance： Colorless to yellowish liquid

Manufacturer supply high quality 1-Bromo-3,4,5-trifluorobenzene 138526-69-9 with GMP standards

  • Molecular Formula:C6H2BrF3
  • Molecular Weight:210.981
  • Appearance/Colour:Colorless to yellowish liquid 
  • Vapor Pressure:1.6mmHg at 25°C 
  • Melting Point:< -20°C 
  • Refractive Index:n20/D 1.482(lit.)  
  • Boiling Point:151.9 °C at 760 mmHg 
  • Flash Point:45 °C 
  • PSA：0.00000 
  • Density:1.784 g/cm3 
  • LogP:2.86640 

5-Bromo-1,2,3-trifluorobenzene(Cas 138526-69-9) Usage

Flammability and Explosibility

Flammable

InChI:InChI:1S/C6H2BrF3/c7-3-1-4(8)6(10)5(9)2-3/h1-2H

138526-69-9 Relevant articles

Green synthesis method of 3,4,5-trifluorobromobenzene

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Paragraph 0026; 0028-0030; 0032-0034; 0036-0038; 0040-0042, (2021/04/10)

The invention discloses a green synthesi...

Preparation method of 3, 4, 5-trifluorobromobenzene

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Paragraph 0104-0106; 0113-0114; 0121, (2020/12/14)

The invention relates to a preparation m...

Preparation method of 3,4,5-trifluorobromobenzene

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Paragraph 0020-0040, (2019/01/05)

The invention belongs to the technical f...

PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES

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Paragraph 00139, (2017/07/28)

The present invention provides a process...

138526-69-9 Process route

1,2,3-trifluorobenzene
1489-53-8

1,2,3-trifluorobenzene

3,4,5-trifluoro-1-bromobenzene
138526-69-9

3,4,5-trifluoro-1-bromobenzene

Conditions
Conditions Yield
With sodium hypochlorite; sodium dihydrogenphosphate; sodium bromide; In dichloromethane; water; at 8 - 15 ℃; for 2.66667h; Temperature;
94.6%
Multi-step reaction with 4 steps
1: 91 percent / sec-butyllithium / tetrahydrofuran; cyclohexane / 1.5 h / -75 °C
2: 95 percent / bromine / CCl4 / Heating
3: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
4: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
With n-butyllithium; bromine; sec.-butyllithium; diisopropylamine; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; cyclohexane;
Multi-step reaction with 5 steps
1: 91 percent / sec-butyllithium / tetrahydrofuran; cyclohexane / 1.5 h / -75 °C
2: 95 percent / bromine / CCl4 / Heating
3: 67 percent / diisopropylamine; butyllithium; tetrabromomethane / hexane; tetrahydrofuran / 2 h / -75 °C
4: 92 percent / butylmagnesium chloride; butyllithium / tetrahydrofuran; hexane; toluene / 0.75 h / 0 °C
5: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
With n-butyllithium; carbon tetrabromide; bromine; sec.-butyllithium; butyl magnesium bromide; diisopropylamine; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; cyclohexane; toluene;
Multi-step reaction with 3 steps
1.1: 91 percent / sec-butyllithium / tetrahydrofuran; cyclohexane / 1.5 h / -75 °C
2.1: 95 percent / bromine / CCl4 / Heating
3.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
3.2: 75 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
With n-butyllithium; bromine; sec.-butyllithium; diisopropylamine; In tetrahydrofuran; tetrachloromethane; hexane; cyclohexane;
Multi-step reaction with 5 steps
1: 95 percent / sec-butyllithium; bromine / tetrahydrofuran; cyclohexane / 45 h / -75 °C
2: 92 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
3: 93 percent / bromine / CCl4 / 36 h / Heating
4: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
5: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
With n-butyllithium; bromine; sec.-butyllithium; diisopropylamine; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; cyclohexane;
Multi-step reaction with 6 steps
1: 95 percent / sec-butyllithium; bromine / tetrahydrofuran; cyclohexane / 45 h / -75 °C
2: 92 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
3: 93 percent / bromine / CCl4 / 36 h / Heating
4: 67 percent / diisopropylamine; butyllithium; tetrabromomethane / hexane; tetrahydrofuran / 2 h / -75 °C
5: 92 percent / butylmagnesium chloride; butyllithium / tetrahydrofuran; hexane; toluene / 0.75 h / 0 °C
6: 89 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
With n-butyllithium; carbon tetrabromide; bromine; sec.-butyllithium; butyl magnesium bromide; diisopropylamine; In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane; cyclohexane; toluene;
Multi-step reaction with 4 steps
1.1: 95 percent / sec-butyllithium; bromine / tetrahydrofuran; cyclohexane / 45 h / -75 °C
2.1: 92 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
3.1: 93 percent / bromine / CCl4 / 36 h / Heating
4.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C
4.2: 75 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C
With n-butyllithium; bromine; sec.-butyllithium; diisopropylamine; In tetrahydrofuran; tetrachloromethane; hexane; cyclohexane;
2-bromo-4,5,6-trifluoroaniline
122375-82-0

2-bromo-4,5,6-trifluoroaniline

3,4,5-trifluoro-1-bromobenzene
138526-69-9

3,4,5-trifluoro-1-bromobenzene

Conditions
Conditions Yield
2-bromo-4,5,6-trifluoroaniline; With nitrosylsulfuric acid; at 10 - 15 ℃; for 6h;
With copper(I) oxide; sodium hypophosphite; sulfuric acid; In water; for 1h;
169 g
2-bromo-4,5,6-trifluoroaniline; With nitrosylsulfuric acid; sulfuric acid; at 7 ℃; for 1h;
With sodium hypophosphite; at 0 - 15 ℃; for 6h; Temperature;

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