Chemical intermediate

1679-18-1

  • Product Name：4-Chlorophenylboronic acid
  • Molecular Formula：C6H6BClO2
  • Specifications：99%
  • Molecular Weight：156.376
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Product Details;

CasNo： 1679-18-1

Molecular Formula： C6H6BClO2

Appearance： off-white to beige crystalline powder

Top Quality Chinese Factory supply 1679-18-1 4-Chlorophenylboronic acid

  • Molecular Formula:C6H6BClO2
  • Molecular Weight:156.376
  • Appearance/Colour:off-white to beige crystalline powder 
  • Vapor Pressure:0.000693mmHg at 25°C 
  • Melting Point:284-289 °C(lit.) 
  • Refractive Index:1.557 
  • Boiling Point:295.4 °C at 760 mmHg 
  • PKA:8.39±0.10(Predicted) 
  • Flash Point:132.4 °C 
  • PSA：40.46000 
  • Density:1.32 g/cm3 
  • LogP:0.01980 

4-Chlorophenylboronic acid(Cas 1679-18-1) Usage

InChI:InChI=1/C6H6BClO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H

1679-18-1 Relevant articles

SYNTHESIS OF ARYLBORONIC ACIDS VIA THE REACTION OF BORANE WITH ARYLMAGNESIUM HALIDES

Kabalka, George W.,Sastry, Usha,Sastry, K.A.R.,Knapp, Furn F.,Srivastava, Prem C.

, p. 269 - 274 (1983)

The reaction of borane complexes with ar...

Preparation method of monohalogenated phenylboronic acid

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Paragraph 0080-0083, (2020/09/20)

The invention relates to the technical f...

Aryl boronic acid preparation method

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Paragraph 0033-0036; 0041, (2020/01/25)

The invention belongs to the technical f...

Synthesis method of P-chlorophenylboronic acid

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Paragraph 0022-0029, (2020/04/22)

The invention belongs to the technical f...

Pd- And Ni-Based Systems for the Catalytic Borylation of Aryl (Pseudo)halides with B2(OH)4

Munteanu, Charissa,Spiller, Taylor E.,Qiu, Jun,Delmonte, Albert J.,Wisniewski, Steven R.,Simmons, Eric M.,Frantz, Doug E.

, p. 10334 - 10349 (2020/09/18)

Despite recent advancements in metal-cat...

1679-18-1 Process route

bromochlorobenzene
106-39-8

bromochlorobenzene

Trimethyl borate
121-43-7,63156-11-6

Trimethyl borate

4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

4-Bromophenylboronic acid
5467-74-3

4-Bromophenylboronic acid

Conditions
Conditions Yield
bromochlorobenzene; With magnesium; In tetrahydrofuran; at 66 ℃; Inert atmosphere;
Trimethyl borate; In tetrahydrofuran; at -20 - -10 ℃; for 6h;
With hydrogenchloride; In water; Overall yield = 26.67 g;
bromochlorobenzene
106-39-8

bromochlorobenzene

4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

Conditions
Conditions Yield
bromochlorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; Inert atmosphere;
With Trimethyl borate; In tetrahydrofuran; hexane; Inert atmosphere;
90%
bromochlorobenzene; With diisobutylaluminium hydride; magnesium; lithium chloride; In tetrahydrofuran; toluene; at 20 ℃; for 0.166667h; Inert atmosphere;
With Trimethyl borate; In tetrahydrofuran; toluene; at 0 ℃; Inert atmosphere;
With hydrogenchloride; water; In tetrahydrofuran; toluene; at 0 ℃; Inert atmosphere;
81%
bromochlorobenzene; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;
With Trimethyl borate; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
74%
bromochlorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -70 ℃; for 1.5h;
With Triisopropyl borate; In tetrahydrofuran; hexane; toluene; at -70 - -20 ℃; Further stages.;
75 % Chromat.
bromochlorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -78 ℃; for 1h; Inert atmosphere;
With Triisopropyl borate; In tetrahydrofuran; hexane; toluene; at -78 ℃; for 1h;
With hydrogenchloride; water; In tetrahydrofuran; hexane; toluene; at -20 - 110 ℃;
bromochlorobenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3h;
With Trimethyl borate; In tetrahydrofuran; at -78 - 20 ℃;
With hydrogenchloride; In tetrahydrofuran; water; for 1h;
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; pentane / 0.06 h / -65 °C / Inert atmosphere
1.2: 0.1 h / -65 °C / Inert atmosphere
2.1: hydrogenchloride; water / Inert atmosphere
With hydrogenchloride; n-butyllithium; water; In tetrahydrofuran; pentane;
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere; Schlenk technique
1.2: -78 - 20 °C / Inert atmosphere; Schlenk technique
2.1: hydrogenchloride / water / 20 °C / Inert atmosphere; Schlenk technique
With hydrogenchloride; n-butyllithium; In tetrahydrofuran; water;
bromochlorobenzene; With magnesium; In tetrahydrofuran; at 20 ℃; for 3h;
With Trimethyl borate; In tetrahydrofuran; at -78 - 20 ℃;
In toluene; for 1h; Reflux; Dean-Stark;
bromochlorobenzene; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; toluene; at -78 - -20 ℃; Inert atmosphere;
With hydrogenchloride; In tetrahydrofuran; hexane; water; toluene; at 10 ℃;
Multi-step reaction with 2 steps
1: magnesium; iodine / toluene; tetrahydrofuran / 2.5 h / 40 - 50 °C / Inert atmosphere
2: hydrogenchloride / 3 h / 20 - 30 °C / pH 2 - 3
With hydrogenchloride; iodine; magnesium; In tetrahydrofuran; toluene;
Multi-step reaction with 2 steps
1: magnesium; iodine / toluene; tetrahydrofuran / 2.5 h / 40 - 50 °C / Inert atmosphere
2: hydrogenchloride / 3 h / 20 - 30 °C / pH 2 - 3
With hydrogenchloride; iodine; magnesium; In tetrahydrofuran; toluene;

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